Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors

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dc.contributor.authorUzunoglu S.
dc.contributor.authorUslu R.
dc.contributor.authorTobu M.
dc.contributor.authorSaydam G.
dc.contributor.authorTerzioglu E.
dc.contributor.authorBuyukkececi F.
dc.contributor.authorOmay S.B.
dc.date.accessioned2024-07-22T08:25:42Z
dc.date.available2024-07-22T08:25:42Z
dc.date.issued1999
dc.description.abstractTo elucidate the roles of serine/threonine protein phosphatases type 1 (PP1) and type 2A (PP2A) in methylprednisolone-induced differentiation of HL60 cells into granulocytes and K562 cells into monocytes, we examined the effect of serine/threonine protein phosphatase inhibitors, okadaic acid and Cal-A on the proliferation/differentiation of HL60 and K562 cells. Okadaic acid and Cal-A augmented methylprednisolone induced granulocytic differentiation and cell death of HL60 cells and monocytic differentiation and cell death of K562 cells in different dose ranges, respectively. These data suggest an important role of PP1 and PP2A in the mechanism leading to differentiation of leukemic cells.
dc.identifier.DOI-ID10.1016/S0145-2126(99)00040-5
dc.identifier.issn01452126
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20558
dc.language.isoEnglish
dc.subjectCell Death
dc.subjectCell Differentiation
dc.subjectEnzyme Inhibitors
dc.subjectHL-60 Cells
dc.subjectHumans
dc.subjectLeukemia, Myeloid
dc.subjectMethylprednisolone
dc.subjectOkadaic Acid
dc.subjectOxazoles
dc.subjectPhosphoprotein Phosphatase
dc.subjectcalyculin a
dc.subjectmethylprednisolone
dc.subjectokadaic acid
dc.subjectphosphoprotein phosphatase inhibitor
dc.subjectarticle
dc.subjectcell death
dc.subjectcell differentiation
dc.subjectcell strain hl 60
dc.subjectcell strain k 562
dc.subjectcontrolled study
dc.subjectdrug potentiation
dc.subjectenzyme inhibition
dc.subjecthuman
dc.subjecthuman cell
dc.subjectleukemia cell
dc.subjectmonocyte
dc.subjectpriority journal
dc.titleAugmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors
dc.typeArticle

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