The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma

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dc.contributor.authorAkin Ocal F.C.
dc.contributor.authorKesici G.G.
dc.contributor.authorGurgen S.G.
dc.contributor.authorOcal R.
dc.contributor.authorErbek S.
dc.date.accessioned2024-07-22T08:08:36Z
dc.date.available2024-07-22T08:08:36Z
dc.date.issued2019
dc.description.abstractObjective To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma.Methods Twenty-eight rats were divided into four groups: Noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups.Results In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma.Conclusion Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment. © 2019 JLO (1984) Limited.
dc.identifier.DOI-ID10.1017/S0022215119001014
dc.identifier.issn00222151
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14466
dc.language.isoEnglish
dc.publisherCambridge University Press
dc.subjectAnimals
dc.subjectBiopsy, Needle
dc.subjectDisease Models, Animal
dc.subjectEvoked Potentials, Auditory, Brain Stem
dc.subjectHearing Loss, Noise-Induced
dc.subjectImmunohistochemistry
dc.subjectInjections, Intralesional
dc.subjectMale
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectOxytocin
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReference Values
dc.subjectSignal-To-Noise Ratio
dc.subjectStatistics, Nonparametric
dc.subjectTreatment Outcome
dc.subjectTympanic Membrane
dc.subjectoxytocin
dc.subjectsynpitan fort
dc.subjectoxytocin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectauditory response
dc.subjectbrain stem response
dc.subjectcochlea tissue
dc.subjectcontrolled study
dc.subjectdistortion product otoacoustic emission
dc.subjectexternal auditory canal
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnoise injury
dc.subjectnonhuman
dc.subjectototoxicity
dc.subjectrat
dc.subjectsignal noise ratio
dc.subjecttherapy effect
dc.subjectwhite noise
dc.subjectanimal
dc.subjectcomparative study
dc.subjectdisease model
dc.subjectdrug effect
dc.subjecteardrum
dc.subjectevoked brain stem auditory response
dc.subjectintralesional drug administration
dc.subjectneedle biopsy
dc.subjectnoise injury
dc.subjectnonparametric test
dc.subjectpathology
dc.subjectrandomization
dc.subjectreference value
dc.subjectspontaneous otoacoustic emission
dc.subjectSprague Dawley rat
dc.subjecttreatment outcome
dc.titleThe effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma
dc.typeArticle

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