Preoperative levels of matrix metalloproteinase-7 and -9 and tissue inhibitor of matrix metalloproteinase-1 relation to pathologic parameters in bladder carcinoma patients

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dc.contributor.authorGunes M.
dc.contributor.authorKemik A.S.
dc.contributor.authorPirincci N.
dc.contributor.authorGecit I.
dc.contributor.authorTaken K.
dc.contributor.authorYuksel M.B.
dc.contributor.authorKaba M.
dc.contributor.authorEryilmaz R.
dc.date.accessioned2024-07-22T08:19:11Z
dc.date.available2024-07-22T08:19:11Z
dc.date.issued2013
dc.description.abstractOur aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.
dc.identifier.DOI-ID10.7314/APJCP.2013.14.2.873
dc.identifier.issn15137368
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17568
dc.language.isoEnglish
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMatrix Metalloproteinase 7
dc.subjectMatrix Metalloproteinase 9
dc.subjectMiddle Aged
dc.subjectTissue Inhibitor of Metalloproteinase-1
dc.subjectTumor Markers, Biological
dc.subjectUrinary Bladder
dc.subjectUrinary Bladder Neoplasms
dc.subjectgelatinase B
dc.subjectmatrilysin
dc.subjectMMP7 protein, human
dc.subjectMMP9 protein, human
dc.subjectTIMP1 protein, human
dc.subjecttissue inhibitor of metalloproteinase 1
dc.subjecttumor marker
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbladder
dc.subjectbladder tumor
dc.subjectblood
dc.subjectdisease course
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.titlePreoperative levels of matrix metalloproteinase-7 and -9 and tissue inhibitor of matrix metalloproteinase-1 relation to pathologic parameters in bladder carcinoma patients
dc.typeArticle

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