Inspiratory flow profile and usability of the NEXThaler, a multidose dry powder inhaler, in asthma and COPD

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dc.contributor.authorChetta A.
dc.contributor.authorYorgancioglu A.
dc.contributor.authorScuri M.
dc.contributor.authorBarile S.
dc.contributor.authorGuastalla D.
dc.contributor.authorDekhuijzen P.N.R.
dc.date.accessioned2024-07-22T08:05:25Z
dc.date.available2024-07-22T08:05:25Z
dc.date.issued2021
dc.description.abstractBackground: Inhaler selection is important when managing respiratory conditions; a patient’s inhalation technique should be appropriate for the selected device, and patients should ideally be able to use a device successfully regardless of disease severity. The NEXThaler is a multidose dry-powder inhaler with a breath-actuated mechanism (BAM) and dose counter that activates only following inhalation, so effectively an ‘inhalation counter’. We assessed inspiratory flow through the NEXThaler in two studies and examined whether inhalation triggered the BAM. Methods: The two studies were open-label, single-arm, and single visit. One study recruited patients with asthma aged ≥ 18 years; the other recruited patients with chronic obstructive pulmonary disease (COPD) aged ≥ 40 years. All patients inhaled twice through a placebo NEXThaler. The inspiratory profile through the device was assessed for each inhalation using acoustic monitoring, with flow at and time to BAM firing, peak inspiratory flow (PIF), and total inhalation time assessed. Results: A total of 40 patients were enrolled in the asthma study: 20 with controlled asthma and 20 with partly controlled/uncontrolled asthma. All patients were able to trigger the BAM, as evidenced by the inhalation counter activating on closing the device. Mean flow at BAM firing following first inhalation was 35.0 (range 16.3–52.3) L/min; mean PIF was 64.6 (35.0–123.9) L/min. A total of 72 patients were enrolled in the COPD study, with data analysed for 69 (mean forced expiratory volume in 1 s 48.7% predicted [17–92%]). As with the asthma study, all patients, regardless of airflow limitation, were able to trigger the BAM. Mean flow at BAM firing following first inhalation was 41.9 (26.6–57.1) L/min; mean PIF was 68.0 (31.5–125.4) L/min. Device usability was rated highly in both studies, with 5 min sufficient to train the patients, and a click heard shortly after inhalation in all cases (providing feedback on BAM firing). Conclusions: Inhalation flows triggering the BAM in the NEXThaler were similar between patients with controlled and partly controlled/uncontrolled asthma, and were similar across COPD airflow limitation. All enrolled patients were able to activate the device. © 2021, The Author(s).
dc.identifier.DOI-ID10.1186/s12890-021-01430-9
dc.identifier.issn14712466
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13134
dc.language.isoEnglish
dc.publisherBioMed Central Ltd
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdministration, Inhalation
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAsthma
dc.subjectDry Powder Inhalers
dc.subjectFemale
dc.subjectHumans
dc.subjectLung
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectRespiratory Function Tests
dc.subjectRespiratory Therapy
dc.subjectYoung Adult
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectasthma
dc.subjectchronic obstructive lung disease
dc.subjectdata analysis
dc.subjectdisease control
dc.subjectevidence based medicine
dc.subjectfemale
dc.subjectfiring rate
dc.subjectforced expiratory volume
dc.subjectforced vital capacity
dc.subjecthuman
dc.subjectinhalation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectopen study
dc.subjectpatient monitoring
dc.subjectpeak inspiratory flow
dc.subjectprediction
dc.subjectadolescent
dc.subjectasthma
dc.subjectchronic obstructive lung disease
dc.subjectdevices
dc.subjectdry powder inhaler
dc.subjectinhalational drug administration
dc.subjectlung
dc.subjectlung function test
dc.subjectmiddle aged
dc.subjectpathophysiology
dc.subjectprocedures
dc.subjectrespiratory care
dc.subjectyoung adult
dc.titleInspiratory flow profile and usability of the NEXThaler, a multidose dry powder inhaler, in asthma and COPD
dc.typeArticle

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