Serum angiotensin-converting enzyme and plasma atrial natriuretic peptide levels in hyperthyroid and hypothyroid rabbits

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dc.contributor.authorYeǧin E.
dc.contributor.authorYiǧitoǧlu M.R.
dc.contributor.authorAri Z.
dc.contributor.authorÇelik I.
dc.contributor.authorAkçay F.
dc.contributor.authorSu̧zek H.
dc.date.accessioned2024-07-22T08:25:51Z
dc.date.available2024-07-22T08:25:51Z
dc.date.issued1997
dc.description.abstractBackground. It is known that serum angiotensin-converting enzyme (ACE) and plasma atrial natriuretic peptide (p-ANP) levels increase in hyperthyroidism. However, the precise mechanism of the effects of thyroid hormone on ANP release remains to be clarified. No study investigating serum ACE together with p-ANP levels has been performed in experimental hyperthyroid and hypothyroid rabbits. The present study was designed in order to provide additional evidence of increased ANP production and secretion in hyperthyroidism and to investigate the relationships between ANP, ACE and thyroid hormones. Methods. Male New Zealand white rabbits (2.3-3.4 kg) were used throughout the study. Hyperthyroidism was induced by daily intraperitoneal administration of L-thyroxin (50 μg/100 g). Hypothyroidism was induced by daily intraperitoneal injection of propylthiouracil (2 mg/100 g body weight). Twelve days after the end of treatment, animals were sacrified under anesthesia and blood samples were obtained from the aorta for serum ACE and thyroid hormone and p-ANP determinations. Results. Serum ACE, plasma renin activity (PRA) and p-ANP were higher in hyperthyroid rabbits and lower in hypothyroid rabbits than in euthyroid rabbits. ANP concentration in atria was lower in hyperthyroid rabbits and higher in hypothyroid rabbits than in euthyroid rabbits. p-ANP, PRA and serum ACE levels were positively correlated with serum thyroxin levels. Inverse correlation was found between serum thyroxin and ANP concentration in atria (a-ANP), and between p-ANP and a-ANP. Conclusions. Our results indicate that not only p-ANP but also serum ACE activity was markedly increased in experimental hyperthyroid rabbits. It was thought that there were both direct and indirect effects of thyroxin on the release of ANP.
dc.identifier.issn00214868
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20632
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAtrial Natriuretic Factor
dc.subjectBlood Pressure
dc.subjectHeart Rate
dc.subjectHyperthyroidism
dc.subjectHypothyroidism
dc.subjectMale
dc.subjectPeptidyl-Dipeptidase A
dc.subjectRabbits
dc.subjectRenin
dc.subjectThyroxine
dc.subjectatrial natriuretic factor
dc.subjectdipeptidyl carboxypeptidase
dc.subjectthyroxine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectenzyme blood level
dc.subjecthyperthyroidism
dc.subjecthypothyroidism
dc.subjectmale
dc.subjectnonhuman
dc.subjectplasma renin activity
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectthyroxine blood level
dc.titleSerum angiotensin-converting enzyme and plasma atrial natriuretic peptide levels in hyperthyroid and hypothyroid rabbits
dc.typeArticle

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