Cardiac functions in children with growth hormone deficiency: Effects of one year of GH replacement therapy

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dc.contributor.authorAlkan F.
dc.contributor.authorErsoy B.
dc.contributor.authorKızılay D.O.
dc.contributor.authorCoskun S.
dc.date.accessioned2024-07-22T08:05:37Z
dc.date.available2024-07-22T08:05:37Z
dc.date.issued2021
dc.description.abstractIntroduction: Children with Growth Hormone deficiency (GHD) are prone to heart dysfunction and, if left untreated, will result in marked cardiac dysfunction in adulthood. The aim was to evaluate the effect of GHD and growth hormone (GH) therapy on cardiac structure in children and adolescents, and to investigate the role of insulin like growth factor-1 (IGF-1) in this. Methods: M-mode, pulse-wave Doppler echocardiography and tissue Doppler imaging (TDI) were performed in 49 children with GHD who were divided into those with a peak GH response < 7 μg/L and 7–10 μg/L after two GH stimulation tests, aged 8–16 years at baseline and at six and 12 months after GH initiation, and 49 healthy peers. IGF-1 concentration was measured. Results: Although the left ventricular end diastolic and systolic diameters in both GH deficient groups were significantly lower than controls (p < 0.01), both diameters increased significantly with one year of treatment and achieved normal values (p > 0.05). Using TDI in both two patients group revealed increased E/A, prolonged isovolumic relaxation time, shortened ejection time, and a significant increase in myocardial performance index compared to controls (p < 0.001). Significant improvement was observed in these parameters from the sixth month of GH treatment (p < 0.001), this improvement does not match parameters measured in healthy peers, even after one year of treatment in both patients group. (p < 0.001). No correlation was found between IGF-1 concentration and any echocardiographic parameter. Conclusion: Echocardiographic parameters were similar in children with a GH peak < 7 μg/L and 7–10 μg/L. In TDI, both systolic and diastolic function was impaired in GHD children compared to controls. These parameters improved after one year of GH therapy but did not recover to healthy control levels. © 2021 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.ghir.2021.101432
dc.identifier.issn10966374
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13198
dc.language.isoEnglish
dc.publisherChurchill Livingstone
dc.subjectCardiovascular Diseases
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectDwarfism, Pituitary
dc.subjectEchocardiography
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHormone Replacement Therapy
dc.subjectHuman Growth Hormone
dc.subjectHumans
dc.subjectInsulin-Like Growth Factor I
dc.subjectMale
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.subjectgrowth hormone
dc.subjectsomatomedin C
dc.subjecthuman growth hormone
dc.subjectIGF1 protein, human
dc.subjectsomatomedin C
dc.subjectadolescent
dc.subjectArticle
dc.subjectbody height
dc.subjectbody weight
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical effectiveness
dc.subjectcontrolled study
dc.subjectdescriptive research
dc.subjectdiastolic blood pressure
dc.subjectDoppler echocardiography
dc.subjectechocardiography
dc.subjectgrowth hormone deficiency
dc.subjectheart function
dc.subjectheart left ventricle enddiastolic diameter
dc.subjectheart left ventricle endsystolic diameter
dc.subjectheart performance
dc.subjectheart ventricle ejection time
dc.subjecthormone substitution
dc.subjecthuman
dc.subjectM mode echocardiography
dc.subjectpediatric patient
dc.subjectsystolic blood pressure
dc.subjecttissue Doppler imaging
dc.subjecttreatment duration
dc.subjectadverse event
dc.subjectcardiovascular disease
dc.subjectcase control study
dc.subjectfemale
dc.subjectfollow up
dc.subjecthormone substitution
dc.subjectmale
dc.subjectmetabolism
dc.subjectpathology
dc.subjectpituitary dwarfism
dc.subjectprognosis
dc.subjectprospective study
dc.subjectrisk factor
dc.titleCardiac functions in children with growth hormone deficiency: Effects of one year of GH replacement therapy
dc.typeArticle

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