Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

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dc.contributor.authorYorukoglu K.
dc.contributor.authorTuna B.
dc.contributor.authorDikicioglu E.
dc.contributor.authorDuzcan E.
dc.contributor.authorIsisag A.
dc.contributor.authorSen S.
dc.contributor.authorMungan U.
dc.contributor.authorKirkali Z.
dc.date.accessioned2024-07-22T08:24:45Z
dc.date.available2024-07-22T08:24:45Z
dc.date.issued2003
dc.description.abstractObjectives: This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification. Methods: A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic). Results: A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications. Conclusions: The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.
dc.identifier.DOI-ID10.1007/s00428-003-0905-0
dc.identifier.issn09456317
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20110
dc.language.isoEnglish
dc.subjectCarcinoma, Papillary
dc.subjectHumans
dc.subjectReproducibility of Results
dc.subjectUrinary Bladder Neoplasms
dc.subjectWorld Health Organization
dc.subjectbladder cancer
dc.subjectcancer classification
dc.subjectcancer grading
dc.subjectclinical article
dc.subjectdiagnostic accuracy
dc.subjectevaluation
dc.subjecthealth care organization
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectnomenclature
dc.subjectobserver variation
dc.subjectpapillary carcinoma
dc.subjectpractice guideline
dc.subjectpriority journal
dc.subjectreproducibility
dc.subjectreview
dc.subjectstandard
dc.subjectstatistical analysis
dc.subjecttechnique
dc.subjecttissue section
dc.subjecturogenital tract cancer
dc.subjectworld health organization
dc.titleReproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder
dc.typeReview

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