The aromatase inhibitor anastrozole is associated with favorable embryo development and implantation markers in mice ovarian stimulation cycles

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dc.contributor.authorKaraer Ö.
dc.contributor.authorVatansever H.S.
dc.contributor.authorOruç S.
dc.contributor.authorÖzbilgin K.
dc.contributor.authorCilaker S.
dc.contributor.authorKoyuncu M.F.
dc.date.accessioned2024-07-22T08:23:52Z
dc.date.available2024-07-22T08:23:52Z
dc.date.issued2005
dc.description.abstractObjective: To investigate the embryonic and endometrial effects of anastrozole in preimplantation and implantation phases in FSH-induced cycles in mice. Design: Blind randomized study. Setting: University research laboratory. Animal(s): Twenty-seven mature female mice. Intervention(s): Single-dose anastrozole (25 mg/kg [0.75 mg]), recombinant FSH (5 IU/mL), and hCG (5 IU/mL) (n = 9); recombinant FSH (5 IU/mL) and hCG (5 IU/mL) (n = 9); or sterile saline (1 mL) (n = 9). The morning of finding the vaginal plug was designated as day 1 of embryonic development (E1). Three mice from each group were sacrificed on E1 and embryos aspirated from uterine tubes. The rest of the mice were sacrificed on E2.5-3 and uteruses removed. Main Outcome Measure(s): Embryo quality, endometrial histologic evaluation, and immunohistochemical analysis of tumor necrosis factor-α, leukemia inhibitory factor, laminin, and collagen IV staining. Result(s): Anastrozole use in FSH-induced cycles not only caused an increase in preimplantation receptivity and implantation but also supported release of implantation markers. The enhanced embryo development seen in this study would explain the higher implantation because embryo development is synchronized with endometrial development. Conclusion(s): In mice, the use of anastrozole in FSH-induced cycles has a positive effect on embryo quality and implantation. This effect might be species dependent, and human studies are needed. ©2005 by American Society for Reproductive Medicine.
dc.identifier.DOI-ID10.1016/j.fertnstert.2005.01.100
dc.identifier.issn00150282
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19736
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectAromatase Inhibitors
dc.subjectBiological Markers
dc.subjectEmbryonic Development
dc.subjectEstrous Cycle
dc.subjectFemale
dc.subjectMale
dc.subjectMice
dc.subjectNitriles
dc.subjectOvulation Induction
dc.subjectTriazoles
dc.subjectanastrozole
dc.subjectaromatase inhibitor
dc.subjectchorionic gonadotropin
dc.subjectcollagen type 4
dc.subjectfollitropin
dc.subjectlaminin
dc.subjectleukemia inhibitory factor
dc.subjectmarker
dc.subjectrecombinant follitropin
dc.subjectsodium chloride
dc.subjecttumor necrosis factor alpha
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectaspiration
dc.subjectcontrolled study
dc.subjectembryo
dc.subjectembryo development
dc.subjectendometrium
dc.subjectfemale
dc.subjecthistology
dc.subjectimmunohistochemistry
dc.subjectlaboratory
dc.subjectmouse
dc.subjectnidation
dc.subjectnonhuman
dc.subjectovary cycle
dc.subjectpreimplantation embryo
dc.subjectpriority journal
dc.subjectprotein secretion
dc.subjectqualitative analysis
dc.subjectrandomization
dc.subjectstaining
dc.subjectstimulation
dc.subjectuniversity
dc.subjectuterine tube
dc.subjectuterus
dc.subjectvagina
dc.titleThe aromatase inhibitor anastrozole is associated with favorable embryo development and implantation markers in mice ovarian stimulation cycles
dc.typeArticle

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