The effects of esmolol on anesthetic and analgesic requirement; [Esmololün anestezik ve analjezik gereksinimi üzerine etkisi]
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Date
2007
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Abstract
Aim: There are many adjuvant agents which decrease the need of anesthetic and analgesic drugs during general anesthesia management. The comparison of the effects of esmolol, a β1 receptor antagonist with a ultra-short-acting, is aimed upon the consumption of analgesic, anesthetic and neuromuscular blocker drugs in this randomized, double-blinded study. Materials and Methods: 18-70 year old, ASA I-II, 60 patients scheduled for elective abdominal operations under general anesthesia were equally divided into 2 groups. In Group E; 1 mg kg-1 esmolol infusion was started slowly prior to induction and 250 μg kg-1 min-1 esmolol infusion lasted during the operation, in Group C (control group) isotonic solution was administered in the same volume. Propofol (due to BIS values) and remifentanil (due to heart beat rate and blood pressure) were administered by TIVA in anesthesia maintenance to the patients. Rocuronium was used as a neuromuscular blocker drug. All hemodynamics values of the cases, the amounts of the anesthetic consumption, analgesic and neuromuscular blocker drugs before and after induction were recorded. Results: There was no difference for age, gender, type and period of operation and induction doses between the groups (p>0.05). The need of analgesic and anesthetic drug was decreased but the consumption of neuromuseular blocker drug not affected in Group E than Group K (p<0.05). Mean arterial blood pressure and heart beat rate variables were more stabile in the perioperative period in Group E. The hemodynamic response to intubation and extubation were reduced by esmolol infusion. Conclusion: The results suggest that the perioperative esmolol administration may reduce intraoperative requirement of the anesthetics and the analgesic to prevent acute autonomic responses during anesthesia and surgery.