Synthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives

Simple item page
dc.contributor.authorAlptuzun V.
dc.contributor.authorCakiroglu G.
dc.contributor.authorLimoncu M.E.
dc.contributor.authorErac B.
dc.contributor.authorHosgor-Limoncu M.
dc.contributor.authorErciyas E.
dc.date.accessioned2024-07-22T08:18:20Z
dc.date.available2024-07-22T08:18:20Z
dc.date.issued2013
dc.description.abstractA series of substituted phenylethylidenehydrazinylpyridinium derivatives bearing methyl, ethyl, propyl, and propylphenyl groups on the pyridinium nitrogen were synthesized and evaluated for in vitro antileishmanial activity against Leishmania tropica by using the microdilution method. Among the tested compounds, 3d, 5c, 3b, and 3c were found to be the most active derivatives against the promastigotes of L. tropica (IC50 values are 6.90, 9.92, 11.69 and 12.03 μM, respectively) and to be more active than reference drug meglumine antimonaite (glucantime) (IC50 value: 20.49 μM). The derivatives investigated in this study may have the potential to be lead compound against leishmanial infection. © 2013 Informa UK, Ltd.
dc.identifier.DOI-ID10.3109/14756366.2012.697058
dc.identifier.issn14756374
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17266
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAntiprotozoal Agents
dc.subjectDose-Response Relationship, Drug
dc.subjectHydrazones
dc.subjectLeishmania tropica
dc.subjectMolecular Structure
dc.subjectParasitic Sensitivity Tests
dc.subjectPyridinium Compounds
dc.subjectStructure-Activity Relationship
dc.subject1 ethyl 4 [2 (1 [4 methoxylphenyl]ethylidene)hydrazinyl] pyridinium bromide
dc.subject1 ethyl 4 [2 (1 [4 methylphenyl]ethylidene)hydrazinyl] pyridinium bromide
dc.subject1 ethyl 4 [2 (1 phenylethylidene)hydrazinyl]pyridinium bromide
dc.subject1 methyl 4 [2 (1 [4 methylphenyl]ethylidene)hydrazinyl] pyridinium iodide
dc.subject1 methyl 4 [2 (1 phenylethylidene)hydrazinyl]pyridinium iodide
dc.subject4 [2 (1 [4 chlorophenyl]ethylidene)hydrazinyl] 1 (3 phenylpropyl)pyridinium bromide
dc.subject4 [2 (1 [4 chlorophenyl]ethylidene)hydrazinyl] 1 ethylpyridinium bromide
dc.subject4 [2 (1 [4 chlorophenyl]ethylidene)hydrazinyl] 1 methylpyridinium iodide
dc.subject4 [2 (1 [4 chlorophenyl]ethylidene)hydrazinyl] 1 propylpyridinium bromide
dc.subject4 [2 (1 [4 methoxylphenyl]ethylidene)hydrazinyl] 1 (3 phenylpropyl)pyridinium bromide
dc.subject4 [2 (1 [4 methoxylphenyl]ethylidene)hydrazinyl] 1 methylpyridinium iodide
dc.subject4 [2 (1 [4 methoxylphenyl]ethylidene)hydrazinyl] 1 propylpyridinium bromide
dc.subject4 [2 (1 [4 methylphenyl]ethylidene)hydrazinyl] 1 (3 phenylpropyl)pyridinium bromide
dc.subject4 [2 (1 [4 methylphenyl]ethylidene)hydrazinyl] 1 propylpyridinium bromide
dc.subject4 [2 (1 phenylethylidene)hydrazinyl] 1 (3 phenylpropyl) pyridinium bromide
dc.subject4 [2 (1 phenylethylidene)hydrazinyl] 1 propyl pyridinium bromide
dc.subjectantileishmanial agent
dc.subjectdimethyl sulfoxide
dc.subjecthydrazone derivative
dc.subjectmeglumine antimonate
dc.subjectphenylethylidenehydrazinylpyridine
dc.subjectpyridine derivative
dc.subjectpyridinium derivative
dc.subjectunclassified drug
dc.subjectantiprotozoal activity
dc.subjectarticle
dc.subjectbacterial growth
dc.subjectbacterial infection
dc.subjectbiological activity
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdrug synthesis
dc.subjectheteronuclear nuclear magnetic resonance
dc.subjectIC 50
dc.subjectin vitro study
dc.subjectLeishmania tropica
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectpromastigote
dc.subjectskin leishmaniasis
dc.titleSynthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives
dc.typeArticle

Files

Collections

Scopus Koleksiyonu