Neurological outcome after cardiac arrest: A prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin

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dc.contributor.authorOk G.
dc.contributor.authorAydin D.
dc.contributor.authorErbüyün K.
dc.contributor.authorGürsoy C.
dc.contributor.authorTaneli F.
dc.contributor.authorBilge S.
dc.contributor.authorDinç Horasan G.
dc.date.accessioned2024-07-22T08:12:18Z
dc.date.available2024-07-22T08:12:18Z
dc.date.issued2016
dc.description.abstractBackground/aim: Factors affecting neurological outcome and the usefulness of neuron-specific enolase (NSE), S-100B, glial fibrillary acidic protein (GFAP), and procalcitonin (PCT) in predicting neurological outcomes were assessed in patients who survived at least 24 h after cardiopulmonary resuscitation (CPR). Materials and methods: Thirty successfully resuscitated cardiac arrest patients were included in this prospective clinical study. The initial cardiac arrest rhythm, duration of CPR, return of spontaneous circulation time, administered doses of adrenaline, base excess, blood sugar, and hemodynamic parameters were recorded. Patients with Glasgow Outcome Scale (GOS) scores of 1–3 were defined as Group I and patients with GOS scores of 4–5 were defined as Group II. Serum NSE, GFAP, S-100B, and PCT levels were compared between the two groups shortly after CPR (hour 0) and at hours 12 and 24 of the postresuscitation period. Results: Serum S-100B was significantly higher (P = 0.009) in Group II immediately after CPR. Serum S-100B and NSE after CPR at hours 0, 12, and 24 were significantly lower in patients who survived to hospital discharge. Serum PCT at hours 12 and 24 and serum S-100B after CPR at 0, 12, and 24 h reached 94.7% sensitivity. Serum NSE, GFAP, S-100B, and PCT specificities were lower than 50%. Conclusion: In predicting neurological outcomes, serum S-100B has high sensitivity and low specificity immediately after CPR. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-1503-64
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15978
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri Journal of Medical Sciences
dc.rightsAll Open Access; Bronze Open Access
dc.subjectBiomarkers
dc.subjectCalcitonin
dc.subjectGlial Fibrillary Acidic Protein
dc.subjectHeart Arrest
dc.subjectHumans
dc.subjectPhosphopyruvate Hydratase
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectS100 Calcium Binding Protein beta Subunit
dc.subjectbiological marker
dc.subjectepinephrine
dc.subjectglial fibrillary acidic protein
dc.subjectglucose
dc.subjectneuron specific enolase
dc.subjectprocalcitonin
dc.subjectprotein S100B
dc.subjectbiological marker
dc.subjectcalcitonin
dc.subjectenolase
dc.subjectglial fibrillary acidic protein
dc.subjectprotein S100B
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectartificial ventilation
dc.subjectcirculation time
dc.subjectclinical article
dc.subjectelectrocardiography
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfollow up
dc.subjectGlasgow outcome scale
dc.subjectheart arrest
dc.subjectheart rhythm
dc.subjectheart ventricle fibrillation
dc.subjectheart ventricle tachycardia
dc.subjecthospital discharge
dc.subjecthuman
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectmiddle aged
dc.subjectprospective study
dc.subjectreceiver operating characteristic
dc.subjectresuscitation
dc.subjectsensitivity and specificity
dc.subjectprognosis
dc.titleNeurological outcome after cardiac arrest: A prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin
dc.typeArticle

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