Relationship between Toxoplasma gondii seropositivity and depression in children and adolescents

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dc.contributor.authorYalın Sapmaz Ş.
dc.contributor.authorŞen S.
dc.contributor.authorÖzkan Y.
dc.contributor.authorKandemir H.
dc.date.accessioned2024-07-22T08:08:27Z
dc.date.available2024-07-22T08:08:27Z
dc.date.issued2019
dc.description.abstractIdentification of the structural causes of depression is important for the treatment process, and toxoplasmosis may be related to psychiatric disorders. The aim of this study was to evaluate the relationship between Toxoplasma gondii (T. gondii) seropositivity and depression in children and adolescents. This case-control study included 37 children and adolescents aged 11–18 years diagnosed with depression who were followed by the Manisa Celal Bayar University Child and Adolescent Mental Health Service and 36 children and adolescents aged 11–18 years with no history of depressive episodes or psychiatric disorder treated by the Pediatric Outpatient Department. The T. gondii serology of these two groups was evaluated and compared. There were no statistically significant age or sex differences between the 37 participants with depression and the 36 healthy controls. Eight patients and two controls were seropositive for T. gondii, a statistically significant difference (p = 0.046). Seropositivity was significantly higher in patients with suicidal ideation (p = 0.005) than in those without suicidal ideation. The seropositivity of seven of the nine participants who attempted suicide was significantly higher (p < 0.001) than that of participants who did not. Thus, T. gondii infection may affect the predisposition for and severity of depression. © 2019
dc.identifier.DOI-ID10.1016/j.psychres.2019.06.031
dc.identifier.issn01651781
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14381
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectAdolescent
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectDepression
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectOutpatients
dc.subjectSuicidal Ideation
dc.subjectToxoplasma
dc.subjectToxoplasmosis
dc.subjectadolescent
dc.subjectadolescent depression
dc.subjectadult
dc.subjectArticle
dc.subjectcase control study
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdisease predisposition
dc.subjectdisease severity assessment
dc.subjectDSM-5
dc.subjectfemale
dc.subjectgene identification
dc.subjectgenotype
dc.subjecthigh risk population
dc.subjecthuman
dc.subjectmale
dc.subjectpriority journal
dc.subjectrisk factor
dc.subjectserology
dc.subjectsuicidal ideation
dc.subjectsuicide attempt
dc.subjectToxoplasma gondii
dc.subjectblood
dc.subjectdepression
dc.subjectmicrobiology
dc.subjectoutpatient
dc.subjectpsychology
dc.subjectToxoplasma
dc.subjecttoxoplasmosis
dc.titleRelationship between Toxoplasma gondii seropositivity and depression in children and adolescents
dc.typeArticle

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