The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancer
| dc.contributor.author | Mutevelizade, G | |
| dc.contributor.author | Kocer, NE | |
| dc.contributor.author | Reyhan, M | |
| dc.date.accessioned | 2025-04-10T10:32:59Z | |
| dc.date.available | 2025-04-10T10:32:59Z | |
| dc.description.abstract | Objective This study aimed to investigate immunohistochemical staining of sodium iodide symporter (NIS) and its effect on response to I-131 therapy in differentiated thyroid carcinoma patients. Methods We evaluated NIS expression, the intracellular distribution of NIS, iodine-131 uptake in residual tissues on post-ablation I-131 whole body scan, and the ablation status after 100 mCi I-131 therapy. We also investigated NIS expression and localization in tumoral paraffin-embedded tissues. Results In this retrospective study, 35 patients (mean age 44.17 +/- 12.9 years, 27 female, 8 male) were studied. Twenty-one of these patients responded to radioiodine therapy, and 14 did not. NIS expression and iodine-131 uptake in residual tissues post-ablation I-131 whole body scan were not statistically significant. When we compared the patients who responded to radioiodine therapy and the poor responder group, NIS expression and iodine-131 uptake in residual tissues did not demonstrate statistically significant difference [(p = 0.308) (p = 0.985) respectively]. 47.6% of the patients in the successful ablation group and 85.7% in the unsuccessful ablation group had intracellular NIS immunostaining. The difference was not statistically significant (p = 0.139). 52.4% of the patients in the successful ablation group and 7% in the unsuccessful ablation group had NIS immunostaining at the basolateral membrane. The difference was statistically significant (p < 0.05). Conclusions In conclusion, we did not find any significant difference between successful and unsuccessful ablation groups in terms of NIS expression; however, we concluded that the intracellular (cytoplasmic) localization of NIS is one of the leading causes of ablation failure regardless of NIS expression in DTC patients. | |
| dc.identifier.e-issn | 1864-6433 | |
| dc.identifier.issn | 0914-7187 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/39311 | |
| dc.language.iso | English | |
| dc.title | The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancer | |
| dc.type | Article |