Effect of renal failure on N-terminal pro-brain natriuretic peptide in patients admitted to emergency department with acute dyspnea

Simple item page
dc.contributor.authorÇolak A.
dc.contributor.authorÇuhadar S.
dc.contributor.authorGölcük B.
dc.contributor.authorGölcük Y.
dc.contributor.authorÖzdoğan Ö.
dc.contributor.authorÇoker B.
dc.date.accessioned2024-07-22T08:15:09Z
dc.date.available2024-07-22T08:15:09Z
dc.date.issued2014
dc.description.abstractObjective: Preexisting renal failure diminishes the excretion of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP), therefore limits the diagnostic value of this peptide for concomitant heart failure. The aim of this study was to evaluate the association between NT-proBNP and the stages of renal dysfunction in a typical population attended to emergency department with acute dyspnea.; Methods: In this cross-sectional study, all consecutive patients with acute dyspnea underwent clinical evaluation, laboratory assessment of NT-proBNP, and echocardiographic examinations. Among subjects, 54.5% were diagnosed as heart failure. Grouping variables according to renal function capacity and ejection fraction, independent variables were compared with Kruskal-Wallis or ANOVA with posthoc tests. Correlation and linear regression analysis were done to analyze the variables associated with NT-proBNP. The diagnostic performance of NT-proBNP was evaluated by receiver-operating characteristic (ROC) curve. ; Results: Serum median NT-proBNP level in patients with severe renal impairment was significantly higher than moderate and mildly decreased renal functions (p=0.001). In patients with moderate and severe left ventricular failure, NT-proBNP was significantly higher compared with normal subjects (LVEF>50%) (p=0.040, and 0.017, respectively). Renal dysfunction was associated in 56% of patients with heart failure. The area under the ROC curve of NT-proBNP for identifying left ventricular failure in patients with renal failure (eGFR<90 mL/min/1.73 m2) was 0.649 and reached significant difference (95% CI:0.548-0.749, p=0.005).; Conclusion: In addition to NT-proBNP measurement in clinical judgement of heart failure, renal functions have to be taken into consideration to avoid misdiagnosis. ©Copyright 2014 by Turkish Society of Cardiology.
dc.identifier.DOI-ID10.5152/akd.2014.4944
dc.identifier.issn13028723
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16694
dc.language.isoEnglish
dc.publisherAVES Ibrahim Kara
dc.subjectBiomarkers
dc.subjectCross-Sectional Studies
dc.subjectDyspnea
dc.subjectEchocardiography
dc.subjectEmergency Service, Hospital
dc.subjectFemale
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectMale
dc.subjectNatriuretic Peptide, Brain
dc.subjectPatient Admission
dc.subjectPeptide Fragments
dc.subjectPredictive Value of Tests
dc.subjectRenal Insufficiency
dc.subjectROC Curve
dc.subjectamino terminal pro brain natriuretic peptide
dc.subjectcreatine kinase MB
dc.subjectcreatinine
dc.subjecthemoglobin
dc.subjectnitrogen
dc.subjecttroponin I
dc.subjecturea
dc.subjectbiological marker
dc.subjectbrain natriuretic peptide
dc.subjectpeptide fragment
dc.subjectpro-brain natriuretic peptide (1-76)
dc.subjectaged
dc.subjectArticle
dc.subjectcross-sectional study
dc.subjectdiagnostic value
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectdyspnea
dc.subjectechocardiography
dc.subjectemergency ward
dc.subjectenzyme immunoassay
dc.subjectfemale
dc.subjectglomerulus filtration rate
dc.subjectheart failure
dc.subjectheart left ventricle ejection fraction
dc.subjecthospital admission
dc.subjecthuman
dc.subjectkidney failure
dc.subjectkidney function
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectquestionnaire
dc.subjectsensitivity and specificity
dc.subjectblood
dc.subjectcomplication
dc.subjectdyspnea
dc.subjectechography
dc.subjectemergency health service
dc.subjectevaluation study
dc.subjectheart failure
dc.subjectkidney failure
dc.subjectpredictive value
dc.subjectreceiver operating characteristic
dc.titleEffect of renal failure on N-terminal pro-brain natriuretic peptide in patients admitted to emergency department with acute dyspnea
dc.typeArticle

Files

Collections

Scopus Koleksiyonu