Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis

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dc.contributor.authorBoyacioglu O.
dc.contributor.authorOrenay-Boyacioglu S.
dc.contributor.authorYildirim H.
dc.contributor.authorKorkmaz M.
dc.date.accessioned2024-07-22T08:09:43Z
dc.date.available2024-07-22T08:09:43Z
dc.date.issued2018
dc.description.abstractThe relationship between daily boron intake and osteocalcin-mediated osteoporosis was studied in boron-exposed postmenopausal women. It is known that boron and osteocalcin are important in bone metabolism, however the effect of boron in bone metabolism has not been fully discovered. The study was performed on 53 postmenopausal women aged 55–60 living in parts of Balikesir, Turkey, where the subjects are naturally exposed to high (≥1 mg/L) or low (<1 mg/L) boron concentration in drinking water. 24-h urine samples were collected from all participants and creatinine clearance was detected. Boron intake levels of the subjects whose clearance levels were between 80–124 mL/min were measured by inductively coupled plasma-optical emission spectrometry (ICP-OES) in urine samples. Serum osteocalcin levels of the subjects were measured by osteocalcin enzyme-linked immunosorbent assay (ELISA) kit. Osteocalcin polymorphism rs1800247 was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Serum osteocalcin levels in boron-exposed postmenopausal women were significantly higher than that of control group (P ≤ 0.05) and the correlation between the serum osteocalcin level and rs1800247 polymorphism was not significant in both groups (P > 0.05). The differences in the distribution of osteocalcin genotypes and alleles in postmenopausal women were not significant between the boron exposed and the control groups (P > 0.05). Serum osteocalcin level in the CC genotype was significantly higher compared to the TC genotype in boron-exposed group (P ≤ 0.05). Our study suggests that daily boron intake of 1 mg/L may affect bone metabolism in postmenopausal women positively. © 2018 Elsevier GmbH
dc.identifier.DOI-ID10.1016/j.jtemb.2018.03.005
dc.identifier.issn0946672X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14942
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectBoron
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectMinerals
dc.subjectOsteocalcin
dc.subjectOsteoporosis, Postmenopausal
dc.subjectPolymorphism, Genetic
dc.subjectboron
dc.subjectcreatinine
dc.subjectdrinking water
dc.subjectosteocalcin
dc.subjectboron
dc.subjectmineral
dc.subjectosteocalcin
dc.subjectadult
dc.subjectallele
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcreatinine clearance
dc.subjectenvironmental exposure
dc.subjectfemale
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmiddle aged
dc.subjectosteocalcin gene
dc.subjectpostmenopause osteoporosis
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectTurkey (republic)
dc.subjectblood
dc.subjectgenetic polymorphism
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectpostmenopause osteoporosis
dc.subjecturine
dc.titleBoron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis
dc.typeArticle

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