Oxidative stress impairs endothelial nitric oxide levels in Behçets' disease

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dc.contributor.authorOnur E.
dc.contributor.authorKabaroglu C.
dc.contributor.authorInanir I.
dc.contributor.authorVar A.
dc.contributor.authorGuvenc Y.
dc.contributor.authorGunay O.
dc.contributor.authorGunduz K.
dc.date.accessioned2024-07-22T08:20:06Z
dc.date.available2024-07-22T08:20:06Z
dc.date.issued2011
dc.description.abstractBackground: Behçet's disease (BD) is an inflammatory vasculitis. Endogenous nitric oxide (NO), produced by endothelial cells, has pleiotropic effects such as vasodilatator, antiplatelet, antiproliferative. Reactive oxygen species (ROS) are produced at sites of endothelial inflammation. ROS target polyunsaturated lipids, which results in malondialdehyde (MDA) production. Objective: The aim was to investigate the oxidative stress in BD patients by measuring MDA and total antioxidant status (TAS) levels and to establish a possible relationship with respect to NO levels regarding disease activity. Materials and methods: 55 BD patients (30 active/25 inactive) and 20 healthy volunteers were included in the study. Blood samples were drawn following an overnight fasting. TAS and MDA levels were determined spectrophotometrically. Serum nitrite (NO 2-) and nitrate (NO 3-) levels were measured to estimate NO production. Data were expressed as mean ± SD. Results: TAS levels were significantly lower in BD patients than the controls (1.19 ± 0.34 vs. 3.29 ± 0.89 mmol/L). In the active BD group, MDA levels (0.36 ± 0.19 nmol/mL) were significantly higher than both the inactive BD group (0.25 ± 0.18 nmol/mL) and controls (0.18 ± 0.41 nmol/mL). NO levels were significantly lower in the active group compared to the inactive group (18.0 ± 2.80 vs. 19.40 ± 2.70 μmol/L). MDA levels correlated negatively with NO levels in the active group. Conclusion: Decreased NO levels mediated by increased oxidative stress significantly contribute to endothelial dysfunction observed in BD. © 2011 Informa Healthcare USA, Inc.
dc.identifier.DOI-ID10.3109/15569527.2011.554480
dc.identifier.issn15569535
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17975
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAntioxidants
dc.subjectBehcet Syndrome
dc.subjectCase-Control Studies
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectHumans
dc.subjectLipid Peroxidation
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectNitrates
dc.subjectNitric Oxide
dc.subjectOxidative Stress
dc.subjectendothelial nitric oxide
dc.subjectmalonaldehyde
dc.subjectnitrate
dc.subjectnitric oxide
dc.subjectnitrite
dc.subjectunclassified drug
dc.subjectadult
dc.subjectarticle
dc.subjectBehcet disease
dc.subjectcontrolled study
dc.subjectdisease activity
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmeasurement
dc.subjectoxidative stress
dc.subjecttotal antioxidant status
dc.titleOxidative stress impairs endothelial nitric oxide levels in Behçets' disease
dc.typeArticle

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