Sorafenib in Metastatic Renal Cell Carcinoma With Sarcomatoid Differentiation

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dc.contributor.authorLekili M.
dc.contributor.authorMuezzinoglu T.
dc.contributor.authorNese N.
dc.contributor.authorTemeltas G.
dc.date.accessioned2024-07-22T08:21:04Z
dc.date.available2024-07-22T08:21:04Z
dc.date.issued2010
dc.description.abstractTargeted therapy in the management of metastatic renal cell cancer has been recently introduced to urology practice. The drugs used for management are used in a very limited number of patients and only for clear cell histology. We present a case where we administered sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, to a patient with metastatic renal cell carcinoma of clear cell histology. We found that our results were different from those of previously reported studies, because sarcomatoid differentiation was evident in a histological examination of this case. There was an excellent response to sorafenib. This case report might provide evidence that antiangiogenic agents may be active in any histological type of renal cell carcinoma. However, there are no available data to demonstrate the duration of response and survival benefit. © 2010 Elsevier.
dc.identifier.DOI-ID10.1016/S1726-4901(10)70056-3
dc.identifier.issn17287731
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18455
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAntineoplastic Agents
dc.subjectBenzenesulfonates
dc.subjectCarcinoma, Renal Cell
dc.subjectHumans
dc.subjectKidney Neoplasms
dc.subjectMale
dc.subjectPyridines
dc.subjectSarcoma
dc.subjectalpha interferon
dc.subjectinterleukin 2
dc.subjectsorafenib
dc.subjectadult
dc.subjectarticle
dc.subjectbrain edema
dc.subjectbrain metastasis
dc.subjectcancer immunotherapy
dc.subjectcancer staging
dc.subjectcase report
dc.subjectclear cell carcinoma
dc.subjectcomputer assisted tomography
dc.subjecthand foot syndrome
dc.subjecthuman
dc.subjectkidney carcinoma
dc.subjectlung metastasis
dc.subjectmale
dc.subjectnephrectomy
dc.subjectpostoperative care
dc.subjectsarcoma
dc.subjectsurvival time
dc.subjecttumor differentiation
dc.titleSorafenib in Metastatic Renal Cell Carcinoma With Sarcomatoid Differentiation
dc.typeArticle

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