Platelet distribution width (PDW): A putative marker for threatened preterm labour

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dc.contributor.authorArtunc Ulkumen B.
dc.contributor.authorPala H.G.
dc.contributor.authorCalik E.
dc.contributor.authorOruc Koltan S.
dc.date.accessioned2024-07-22T08:17:30Z
dc.date.available2024-07-22T08:17:30Z
dc.date.issued2014
dc.description.abstractObjective: To determine the alterations of mean platelet volume (MPV), platelet distribution width (PDW), platelet level and hemoglobin level in pregnancies with threatened preterm labor (TPL). Methods: The retrospective analysis of 201 pregnant women with threatened preterm labour admitted to our clinic between 2009 and 2013 and 192 healthy pregnancies was conducted. The data regarding the maternal age, hemoglobin level, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) was evaluated. Results: The mean MPV and hemoglobin levels were significantly lower in TPL group (p=0.001 and p=0.01, respectively). PDW levels were significantly higher in TPL group (p=0.05). (p=0.01). Regarding the platelet count, there was no statistically significant difference between the TPL and control groups. ROC curve analysis for PDW revealed an area under curve (AUC) 66.8%. By using a cut-off value 16.15 for PDW, sensitivity was 76.1% and specificity was 43.5% for TPL. Conclusion: MPV seems to be lower in threatened preterm deliveries, whereas PDW levels were increased suggesting the possible high grade inflammation and platelet activation in the pathology. Anemia occurs more frequently in threatened preterm delivery. Increased PDW levels especially > 16.15 may alert the obstetrician for the risk of the preterm delivery. However, further studies are needed to state the usefulness of the platelet indices in the diagnosis and clinical follow-up of preterm labor.
dc.identifier.DOI-ID10.12669/pjms.304.4991
dc.identifier.issn1682024X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17070
dc.language.isoEnglish
dc.publisherProfessional Medical Publications
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjecthemoglobin
dc.subjectadult
dc.subjectanemia
dc.subjectarticle
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollow up
dc.subjectgestational age
dc.subjecthematological parameters
dc.subjecthemoglobin blood level
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmaternal age
dc.subjectparity
dc.subjectplatelet distribution width
dc.subjectpremature labor
dc.subjectretrospective study
dc.subjectrisk assessment
dc.subjectsensitivity and specificity
dc.subjectthrombocyte activation
dc.subjectthrombocyte volume
dc.titlePlatelet distribution width (PDW): A putative marker for threatened preterm labour
dc.typeArticle

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