The effects of clarithromycin treatment on cardiac events in acute coronary syndrome patients; [Akut Koroner Sendromlu Hastalarda Klaritromisin Tedavisinin Kardiyak Olaylar Üzerine Etkisi]

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dc.contributor.authorÜtük O.
dc.contributor.authorŞekuri C.
dc.contributor.authorBayturan Ö.
dc.contributor.authorBilge A.R.
dc.contributor.authorTikiz H.
dc.contributor.authorTavli T.
dc.contributor.authorTezcan U.K.
dc.date.accessioned2024-07-22T08:24:15Z
dc.date.available2024-07-22T08:24:15Z
dc.date.issued2004
dc.description.abstractObjective: The assessment of short duration early clarithromycin treatment on major cardiac events in acute coronary syndrome patients. Methods: One hundred and thirteen patients with acute coronary syndrome had been enrolled in the study in a prospective manner. Fifty-seven of 113 patients received peroral clarithromycin 1 g/day for 14 days in addition to standard therapy. The remaining 56 patients were considered as control group. The treatment and control groups had similar major cardiac risk factors such as diabetes, hypertension, dyslipidemia and smoking habits. The occurrence of unstable angina pectoris, non-ST elevation myocardial infarction and ST elevation myocardial infarction was comparable in both groups. The use of thrombolytic therapy and glycoprotein IIb/IIIa receptor blockers administration was also similar in both groups. The patients were followed for major cardiac events for 6 months. Results: During the follow-up, no difference was observed between groups in the occurrence of unstable angina pectoris, myocardial infarction, the need for revascularization with percutaneous coronary intervention or cardiac surgery and cardiac death. We observed a reduction of myocardial infarction and cardiac death occurrence and an increase in the necessity of percutaneous interventions in the treatment group even though this difference did not reach statistical significance. Conclusion: No benefit of short duration early clarithromycin therapy was observed in the occurrence of major cardiac events in acute coronary syndromes. Studies with longer treatment and follow-up period using different antibiotics are necessary to elucidate the possible effect of antibiotics on major cardiac events in patients with acute coronary syndrome.
dc.identifier.issn13028723
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19879
dc.language.isoTurkish
dc.subjectAdministration, Oral
dc.subjectAnti-Bacterial Agents
dc.subjectClarithromycin
dc.subjectDrug Administration Schedule
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectProspective Studies
dc.subjectTreatment Outcome
dc.subjectacetylsalicylic acid
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectclarithromycin
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectfibrinogen receptor antagonist
dc.subjectfibrinolytic agent
dc.subjectheparin
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcardiovascular risk
dc.subjectclinical observation
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectdose response
dc.subjectdrug efficacy
dc.subjectdyslipidemia
dc.subjectfemale
dc.subjectfollow up
dc.subjectheart death
dc.subjectheart disease
dc.subjectheart infarction
dc.subjectheart muscle ischemia
dc.subjectheart muscle revascularization
dc.subjectheart surgery
dc.subjecthuman
dc.subjecthypertension
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpercutaneous coronary intervention
dc.subjectprospective study
dc.subjectshort course therapy
dc.subjectsmoking habit
dc.subjectST segment elevation
dc.subjectstatistical significance
dc.subjectunstable angina pectoris
dc.titleThe effects of clarithromycin treatment on cardiac events in acute coronary syndrome patients; [Akut Koroner Sendromlu Hastalarda Klaritromisin Tedavisinin Kardiyak Olaylar Üzerine Etkisi]
dc.typeArticle

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