Investigation the in vitro biological performance of graphene/bioactive glass scaffolds using MC3T3-E1 and ATDC5 cells

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dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorTürk M.
dc.date.accessioned2024-07-22T08:09:29Z
dc.date.available2024-07-22T08:09:29Z
dc.date.issued2018
dc.description.abstractSilicate-based bioactive glass constructs were fabricated by polymer foam replication method for tissue engineering applications. Composites were prepared by coating the surface of bioactive glass scaffolds with poly(ε-caprolactone) involving graphene nanopowders at different concentrations. In vitro bioactivity of the composite constructs was tested in simulated body fluid. Additionally, the response of pre-osteoblastic MC3T3-E1 and chondrogenic ATDC5 cells were investigated under in vitro conditions. Results revealed that a decrease was not observed in acellular bioactivity of the scaffolds. Cell viability experiments showed that graphene involving samples were not cytotoxic to the MC3T3-E1 and ATDC5 cells (except for the samples containing 10 wt% graphene) and cells proliferated well on the scaffolds. Additionally, the pre-osteoblastic cells seeded onto the composite scaffolds differentiated into osteoblasts. The scaffolds prepared in this study may find applications for bone and cartilage tissue engineering in the presence of electric stimulation. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/10667857.2018.1517994
dc.identifier.issn10667857
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14846
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.subjectBioactive glass
dc.subjectCell culture
dc.subjectElectrophysiology
dc.subjectElectrotherapeutics
dc.subjectGraphene
dc.subjectMedical applications
dc.subjectOsteoblasts
dc.subjectSilicates
dc.subjectTissue
dc.subjectATDC5
dc.subjectBiological performance
dc.subjectBiomedical applications
dc.subjectElectric stimulation
dc.subjectMC3T3-E1
dc.subjectPoly (epsiloncaprolactone)
dc.subjectSimulated body fluids
dc.subjectTissue engineering applications
dc.subjectScaffolds (biology)
dc.titleInvestigation the in vitro biological performance of graphene/bioactive glass scaffolds using MC3T3-E1 and ATDC5 cells
dc.typeArticle

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