Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users

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dc.contributor.authorOruç S.
dc.contributor.authorVatansever H.S.
dc.contributor.authorKaraer Ö.
dc.contributor.authorEskicioǧlu F.
dc.contributor.authorNarlikuyu B.
dc.date.accessioned2024-07-22T08:23:51Z
dc.date.available2024-07-22T08:23:51Z
dc.date.issued2005
dc.description.abstractIntrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical distribution patterns of αv, α3, β1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the role of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteal phases and in menopausal women grouped according to the period of time of IUD use (group 1: <3 year, and group 2: ≥3 years). Each group consisted of 10 patients, with a total number of 60 patients. Labelling intensity of all integrins, except for β1 which increased in the follicular phase, were decreased in women who used IUD for ≥3 years when compared with group 1 in the follicular and luteal phases and in the menopause. We conclude that long-term use of IUD affects integrin expression in endometrium not only in follicular and luteal phases of premenopausal women but also in postmenopausal women. Copper IUD can inhibit binding of integrins to the extracellular matrix and it may cause inhibition of the implantation stage, which is crucial for pregnancy. © 2005 Elsevier GmbH. All rights reserved.
dc.identifier.DOI-ID10.1016/j.acthis.2005.01.001
dc.identifier.issn00651281
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19727
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectCell membranes
dc.subjectCost effectiveness
dc.subjectHistology
dc.subjectImmunology
dc.subjectImplants (surgical)
dc.subjectMedical applications
dc.subjectPatient monitoring
dc.subjectintegrin
dc.subjectExtracellular matrix
dc.subjectImmunohistochemical distribution patterns
dc.subjectIntrauterine contraceptions
dc.subjectIntrauterine devices (IUD)
dc.subjectarticle
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectendometrium
dc.subjectendometrium biopsy
dc.subjectextracellular matrix
dc.subjectfemale
dc.subjectfollicular phase
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimplantation
dc.subjectintrauterine contraceptive device
dc.subjectluteal phase
dc.subjectmenopause
dc.subjectpostmenopause
dc.subjectpregnancy
dc.subjectpremenopause
dc.subjectprotein binding
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectprotein localization
dc.subjectPattern recognition
dc.titleChanges in distribution patterns of integrins in endometrium in copper T380 intrauterine device users
dc.typeArticle

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