GSTP1 gene methylation profiles in Helicobacter pylori (+) and (-) antral intestinal metaplasia and distal gastric tumour patients in Turkish population

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dc.contributor.authorAsik-Sen G.
dc.contributor.authorKasap E.
dc.contributor.authorOrenay-Boyacioglu S.
dc.contributor.authorKorkmaz M.
dc.contributor.authorKahraman E.
dc.contributor.authorUnsal B.
dc.contributor.authorYüksel-Saritas E.
dc.contributor.authorYuceyar H.
dc.date.accessioned2024-07-22T08:19:15Z
dc.date.available2024-07-22T08:19:15Z
dc.date.issued2012
dc.description.abstractBackground/Aims: Gastric cancer (GC) is the second most common malignancy worldwide, with a high mortality rate. The incidence of GC has declined in the western countries during the last decades. The glutathione S-transferases comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study we aimed at the relationship GSTP-1 methylation in patients with intestinal metaplasia with and without Helicobacter pylori infection, gastric cancer and controls. Methodology: The methylation status of GSTP1 gene was analyzed by methylation specific PCR after bisulfate modification in H. pylori (+) (n=25) and (-) (n=25) intestinal metaplasia (IM) patients, GC (n=25) and control subjects (n=15) between September 2009 to November 2011. Results: During the study period 90 patients who underwent endoscopic examination were included in the study. When we considered the GSTP1 gene methylation profile in all of the groups; 26 (28%) patients had methylated GSTP1 gene, 31 (34%) patients had unmethylated GSTP1 gene and 33 (36%) patients had heterogeneously methylated GSTP1 gene. Conclusions: GSTP1 gene methylation profile is not appropriate for early diagnosis of cases with gastric cancer. © H.G.E. Update Medical Publishing S.A.
dc.identifier.DOI-ID10.5754/hge12148
dc.identifier.issn01726390
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17579
dc.language.isoEnglish
dc.subjectAdult
dc.subjectBiopsy
dc.subjectCase-Control Studies
dc.subjectChi-Square Distribution
dc.subjectDNA Methylation
dc.subjectEarly Detection of Cancer
dc.subjectFemale
dc.subjectGastroscopy
dc.subjectGenetic Predisposition to Disease
dc.subjectGlutathione S-Transferase pi
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectMale
dc.subjectMetaplasia
dc.subjectMiddle Aged
dc.subjectPhenotype
dc.subjectPolymerase Chain Reaction
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectPyloric Antrum
dc.subjectStomach Neoplasms
dc.subjectTurkey
dc.subjectglutathione transferase P1
dc.subjectadult
dc.subjectarticle
dc.subjectDNA methylation
dc.subjectendoscopy
dc.subjectfemale
dc.subjectHelicobacter pylori
dc.subjecthuman
dc.subjectintestine metaplasia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectstomach cancer
dc.subjectTurkey (republic)
dc.titleGSTP1 gene methylation profiles in Helicobacter pylori (+) and (-) antral intestinal metaplasia and distal gastric tumour patients in Turkish population
dc.typeArticle

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