Beneficial effects of apricot-feeding on myocardial ischemia-reperfusion injury in rats

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dc.contributor.authorParlakpinar H.
dc.contributor.authorOlmez E.
dc.contributor.authorAcet A.
dc.contributor.authorOzturk F.
dc.contributor.authorTasdemir S.
dc.contributor.authorAtes B.
dc.contributor.authorGul M.
dc.contributor.authorOtlu A.
dc.date.accessioned2024-07-22T08:21:40Z
dc.date.available2024-07-22T08:21:40Z
dc.date.issued2009
dc.description.abstractThe present study was undertaken to evaluate the cardio-protective potential of apricot-feeding in the ischemia-reperfusion (I/R) model of rats in vivo. Rats were divided into three groups of 12 rats each. Group 1 was fed with a standard rat chow, groups 2 and 3 were fed with a standard rat chow supplemented with 10% or 20% dried apricot during 3 months before the beginning of I/R studies. To produce I/R, the left main coronary artery was occluded for 30 min, followed by 120 min reperfusion, in anesthetized rats. Infarct sizes were found significantly decreased in 10% (55.0 ± 4.3%) and 20% (57.0 ± 2.9%) apricot-fed groups compared to control group (68.7 ± 2.0%). Light and electron microscopic evaluations of hearts also demonstrated similar beneficial effects on I/R injury in apricot-fed both groups. Total phenolic contents, DPPH radical scavenging and ferric-reducing power as in vitro antioxidant capacities of rat chows were significantly increased after supplementation with apricot for each ratio. Cu, Zn Superoxide dismutase (Cu, Zn SOD) and catalase (CAT) activities were increased, and lipid peroxidation was decreased significantly in the hearts of 20% apricot-fed group after I/R. In conclusion, we clearly demonstrated in vivo cardio-protective activity of apricot-feeding related to its antioxidant phenolic contents in rats subjected to myocardial I/R. © 2009 Elsevier Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.fct.2009.01.014
dc.identifier.issn02786915
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18729
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectElectrocardiography
dc.subjectHemodynamics
dc.subjectMale
dc.subjectMyocardial Infarction
dc.subjectMyocardial Reperfusion Injury
dc.subjectPlant Extracts
dc.subjectPrunus
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectPrunus armeniaca
dc.subjectRattus
dc.subject1,1 diphenyl 2 picrylhydrazyl
dc.subjectantioxidant
dc.subjectapricot extract
dc.subjectcatalase
dc.subjectcopper
dc.subjectferric ion
dc.subjectphenol
dc.subjectplant extract
dc.subjectsuperoxide dismutase
dc.subjectunclassified drug
dc.subjectzinc
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectapricot
dc.subjectartery occlusion
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdiet therapy
dc.subjectelectron microscopy
dc.subjectenzyme activity
dc.subjectheart
dc.subjectheart infarction size
dc.subjectheart muscle ischemia
dc.subjectheart protection
dc.subjectin vivo study
dc.subjectleft coronary artery
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectreduction kinetics
dc.subjectreperfusion injury
dc.titleBeneficial effects of apricot-feeding on myocardial ischemia-reperfusion injury in rats
dc.typeArticle

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