The performance of Khorana risk score for prediction of venous thromboembolism in patients with lung cancer: A retrospective cohort study; [Akciğer kanserli hastalarda venöz tromboembolizmin tahmininde Khorana risk skorunun performansı: Retrospektif kohort çalışma]

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dc.contributor.authorKizilirmak D.
dc.contributor.authorFidan U.
dc.contributor.authorHavlucu Y.
dc.date.accessioned2024-07-22T08:01:43Z
dc.date.available2024-07-22T08:01:43Z
dc.date.issued2024
dc.description.abstractIntroduction: Cancer-related venous thromboembolism is one of the leading causes of mortality and morbidity in cancer patients. Lung cancer is the second most common cancer in the world and is closely related to venous thromboembolism. Venous thromboembolism affects survival in patients with cancer and it is important to be able to predict the possibility of thrombosis in patients with cancer. It was aimed to evaluate the predictive performance of the Khorana risk score in patients with lung cancer. Materials and Methods: The medical data of the patients followed up with lung cancer were analyzed retrospectively. Venous thromboembolism events in lung cancer patients were described. The relationship between the Khorana risk score and the risk of venous thromboembolism was investigated using the cumulative incidence function with compared risk models. Results: Eight hundred fourteen lung cancer patients were included in the study. Venous thromboembolism was detected in 79 (9.7%) of the patients. Sixty one (77.2%) of the patients had pulmonary embolism, 15 (19%) had peripheral deep vein thrombosis and three (3.8%) had venous thrombosis of other sites. The cumulative incidences of venous thromboembolism for high and intermediate Khorana risk scores were 10.1% and 9.7%, respectively (p= 0.09). The cumulative incidences of venous thromboembolism at 3, 6, 12, and 24 months were 4.7%, 5.8%, 6.4%, and 9.6% for the high-grade Khorana risk score; 4.6%, 5.7%, 6.3% and 7.8% for the intermediate Khorana risk score (p= 0.11). Conclusion: The Khorana risk score was not found useful in the risk stratification of venous thromboembolism (intermediate or high risk) in patients with lung cancer. New scoring systems are needed to calculate the risk of venous thromboembolism in patients with lung cancer. © 2024 by Tuberculosis and Thorax.
dc.identifier.DOI-ID10.5578/tt.202402921
dc.identifier.issn04941373
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11566
dc.language.isoEnglish
dc.publisherAnkara University
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPredictive Value of Tests
dc.subjectPulmonary Embolism
dc.subjectRetrospective Studies
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectVenous Thromboembolism
dc.subjecthemoglobin
dc.subjectadult
dc.subjectArticle
dc.subjectbody mass
dc.subjectcancer chemotherapy
dc.subjectcancer palliative therapy
dc.subjectcancer radiotherapy
dc.subjectcancer staging
dc.subjectcancer surgery
dc.subjectchronic kidney failure
dc.subjectchronic obstructive lung disease
dc.subjectcohort analysis
dc.subjectcumulative incidence
dc.subjectdeep vein thrombosis
dc.subjectdiabetes mellitus
dc.subjectdisease risk assessment
dc.subjectfemale
dc.subjectfollow up
dc.subjecthigh risk population
dc.subjecthuman
dc.subjectintermediate risk population
dc.subjectischemic heart disease
dc.subjectKhorana risk score
dc.subjectleukocyte count
dc.subjectlung cancer
dc.subjectlung embolism
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectneurologic disease
dc.subjectnon small cell lung cancer
dc.subjectplatelet count
dc.subjectretrospective study
dc.subjectrheumatic disease
dc.subjectsmall cell lung cancer
dc.subjectvein thrombosis
dc.subjectvenous thromboembolism
dc.subjectaged
dc.subjectcomplication
dc.subjectepidemiology
dc.subjectetiology
dc.subjectincidence
dc.subjectlung tumor
dc.subjectpredictive value
dc.subjectprocedures
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectvenous thromboembolism
dc.titleThe performance of Khorana risk score for prediction of venous thromboembolism in patients with lung cancer: A retrospective cohort study; [Akciğer kanserli hastalarda venöz tromboembolizmin tahmininde Khorana risk skorunun performansı: Retrospektif kohort çalışma]
dc.typeArticle

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