Endothelial dysfunction in patients with primary Sjögren's syndrome

Simple item page
dc.contributor.authorPirildar T.
dc.contributor.authorTikiz C.
dc.contributor.authorÖzkaya S.
dc.contributor.authorTarhan S.
dc.contributor.authorÜtük O.
dc.contributor.authorTikiz H.
dc.contributor.authorTezcan U.K.
dc.date.accessioned2024-07-22T08:23:51Z
dc.date.available2024-07-22T08:23:51Z
dc.date.issued2005
dc.description.abstractThe aim of this study was to determine the endothelial function in patients with primary Sjögren's syndrome (SS). We also aimed to determine whether endothelial (dys)function correlates with extraglandular manifestations, specific autoantibodies and the severity of salivary gland involvement of SS. Endothelium-dependent vasodilation and endothelium-independent vasodilation of the brachial artery were assessed by a high-resolution ultrasound on 25 patients with primary SS and on 29 healthy controls. Patients with primary SS had significantly less mean endothelium-dependent vasodilation than did controls (3.0±0.4% vs 4.2±0.3%; p=0.012). Endothelium-independent vasodilation induced by sublingual glycerol trinitrate was not different between the two groups (12.9±1.4% vs 14.1±1.2%; p=0.86;). We concluded that endothelium-dependent vasodilation was impaired in primary SS patients, in particular those presenting with Raynaud's phenomenon, when compared with the healthy controls and this impairment was not associated with the presence of RF, ANA, anti-Ro/SS-A, anti-La/SS-B and with the other extraglandular manifestations of the disease. © Springer-Verlag 2005.
dc.identifier.DOI-ID10.1007/s00296-005-0599-5
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19719
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAntibodies, Antinuclear
dc.subjectBiopsy, Needle
dc.subjectCase-Control Studies
dc.subjectDisease Progression
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProbability
dc.subjectPrognosis
dc.subjectReference Values
dc.subjectSalivary Glands
dc.subjectSeverity of Illness Index
dc.subjectSex Factors
dc.subjectSjogren's Syndrome
dc.subjectStatistics, Nonparametric
dc.subjectantinuclear antibody
dc.subjectautoantibody
dc.subjectglyceryl trinitrate
dc.subjectLa antibody
dc.subjectrheumatoid factor
dc.subjectRo antibody
dc.subjectadult
dc.subjectarticle
dc.subjectbrachial artery
dc.subjectcell function
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectendothelium cell
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlacrimal gland function
dc.subjectmale
dc.subjectpriority journal
dc.subjectRaynaud phenomenon
dc.subjectsalivary gland
dc.subjectsalivary gland biopsy
dc.subjectsalivation
dc.subjectSjoegren syndrome
dc.subjectultrasound
dc.subjectvasodilatation
dc.titleEndothelial dysfunction in patients with primary Sjögren's syndrome
dc.typeArticle

Files

Collections

Scopus Koleksiyonu