Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma
No Thumbnail Available
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other. A total of 37 male patients with renal cell cancer and with a mean age of 56.28 ± 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 ± 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at −20°C until they were used. Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower (p < 0.05). Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer. © 2013, SAGE Publications. All rights reserved.
Description
Keywords
Antioxidants , Carcinoma, Renal Cell , Case-Control Studies , Dipeptidases , Glutathione , Glutathione Peroxidase , Glutathione Transferase , Humans , Male , Malondialdehyde , Middle Aged , Oxidative Stress , Superoxide Dismutase , antioxidant , dipeptidase , glutathione , glutathione peroxidase , glutathione transferase , malonaldehyde , proline dipeptidase , superoxide dismutase , glutathione , glutathione peroxidase , glutathione transferase , malonaldehyde , proline dipeptidase , superoxide dismutase , blood , case control study , human , kidney carcinoma , male , middle aged , oxidative stress , adult , antioxidant activity , Article , biochemical analysis , cancer patient , clinical article , controlled study , enzyme blood level , kidney carcinoma , lipid peroxidation