Hyperbaric oxygen treatment in the experimental spinal cord injury model

Simple item page
dc.contributor.authorYaman O.
dc.contributor.authorYaman B.
dc.contributor.authorAydin F.
dc.contributor.authorVar A.
dc.contributor.authorTemiz C.
dc.date.accessioned2024-07-22T08:15:04Z
dc.date.available2024-07-22T08:15:04Z
dc.date.issued2014
dc.description.abstractBackground context Spinal cord trauma is a major cause of mortality and morbidity. Although no known treatment for spinal cord injury exists, a limited number of effective treatment modalities and procedures are available that improve secondary injury. Hyperbaric oxygen (HBO) treatment has been used to assist in neurologic recovery after cranial injury or ischemic stroke. Purpose To report the findings on the effectiveness of HBO treatment on rats with experimental traumatic spinal cord injury. Improvement was evaluated through motor strength assessment and nitrite level assay testing. Study design We randomly distributed 40 rats among 5 groups of 8 rats each: sham incurable trauma, induced trauma, HBO treatment begun at the 1st hour, HBO treatment begun at the 6th hour, and HBO treatment begun at the 24th hour. Method The HBO treatment was administered to rats in three of the groups and conducted in two 90-minute sessions, under an absolute atmospheric pressure of 2.4 at 100% oxygen for 5 days. In the motor strength evaluations, all the rats were observed during the inclined plane test and clinical motor examination on the first, third, and fifth days. In addition, the nitrite levels of spinal cord tissues on the sixth day were also studied. Results Results from the inclined plane levels and motor strength test from all the three groups undergoing HBO treatment were higher than those from Group 2. It was also determined that early HBO treatment resulted in higher recovery rates (groups 3 and 4). The highest levels were seen in the group in which the HBO treatments were started in the first hour (Group 3). It was noted that nitrite levels of rats in the group exposed to trauma increased, compared with the sham group, but increased levels also diminished after HBO treatments. Again, the greatest decrease in nitrite levels was evident in the group where the HBO treatment was started the earliest (Group 3). Conclusions Prompt HBO treatment after trauma significantly contributed to the clinical, histopathologic, and biochemical recovery of the rats. © 2014 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.spinee.2014.02.013
dc.identifier.issn15299430
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16672
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectHyperbaric Oxygenation
dc.subjectMale
dc.subjectNitrites
dc.subjectRats
dc.subjectRecovery of Function
dc.subjectSpinal Cord
dc.subjectSpinal Cord Injuries
dc.subjectTime-to-Treatment
dc.subjectTreatment Outcome
dc.subjectnitrite
dc.subjectoxygen
dc.subjectnitrite
dc.subjectabscess
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectatmospheric pressure
dc.subjectbleeding
dc.subjectcontrolled study
dc.subjectedema
dc.subjectexperimental spinal cord injury
dc.subjecthistopathology
dc.subjecthyperbaric oxygen
dc.subjectinflammatory cell
dc.subjectlaminectomy
dc.subjectmotor performance
dc.subjectnonhuman
dc.subjectparaplegia
dc.subjectpriority journal
dc.subjectrat
dc.subjectsham procedure
dc.subjecttissue necrosis
dc.subjectanimal
dc.subjectconvalescence
dc.subjectdisease model
dc.subjecthyperbaric oxygen
dc.subjectmale
dc.subjectmetabolism
dc.subjectpathology
dc.subjectprocedures
dc.subjectspinal cord
dc.subjectSpinal Cord Injuries
dc.subjecttime to treatment
dc.subjecttreatment outcome
dc.titleHyperbaric oxygen treatment in the experimental spinal cord injury model
dc.typeArticle

Files

Collections

Scopus Koleksiyonu