Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori

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dc.contributor.authorDemirci U.
dc.contributor.authorOrenay-Boyacioglu S.
dc.contributor.authorKasap E.
dc.contributor.authorGerçeker E.
dc.contributor.authorBilgiç F.
dc.contributor.authorYüceyar H.
dc.contributor.authorYildirim H.
dc.contributor.authorBaykan A.R.
dc.contributor.authorEllidokuz E.B.
dc.contributor.authorKorkmaz M.
dc.date.accessioned2024-07-22T08:02:50Z
dc.date.available2024-07-22T08:02:50Z
dc.date.issued2023
dc.description.abstractBackground and study aims: Intestinal metaplasia (IM), and Helicobacter pylori (HP) infection can be shown as risk factors in the development of gastric cancer (GC). WNT signaling pathway plays a critical role in carcinogenesis. However, the literature studies are limited on the significance of this pathway for the transition from IM to GC. Patients and methods: We aimed to investigate the importance of the genes of WNT signaling pathways diagnostic and prognostic markers in the presence and absence of HP in conversion from IM to GC. 104 patients, (GC group n = 35, IM group n = 45, control group n = 25) were included in this case-control study. Expression of genes in WNT signalling were searched in study groups with qRT-PCR array and qRT-PCR method. Data were analysed using PCR array data analysis software. Results: Statistically significant overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes was detected in the GC and IM groups compared to the control group (p < 0.05). Statistically significant overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes was observed in patients with metastatic GC compared to patients with GC without metastasis (p < 0.05). It was found that the RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes were statistically significantly over-expressed in diffuse GC patients compared to non-diffuse GC patients (p < 0.05). Statistically significant overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes was detected in HP positive IM patients compared to HP negative IM patients (p < 0.05). Conclusion: Overexpression of RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes in IM may suggest that these genes are important markers in the development of IM and inflammation with HP. In addition, these genes are linked to tumor burden in the GC group. Consequently, we can conclude that these genes are poor prognosis biomarkers for GC and have the potential to be used as markers for future treatment monitoring. © 2023 Pan-Arab Association of Gastroenterology
dc.identifier.DOI-ID10.1016/j.ajg.2023.01.004
dc.identifier.issn16871979
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12018
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Green Open Access
dc.subjectCase-Control Studies
dc.subjectDishevelled Proteins
dc.subjectGastric Mucosa
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectLow Density Lipoprotein Receptor-Related Protein-5
dc.subjectrhoA GTP-Binding Protein
dc.subjectRisk Factors
dc.subjectStomach Neoplasms
dc.subjectcasein kinase Ialpha
dc.subjectdishevelled 2
dc.subjectfrizzled protein
dc.subjectlow density lipoprotein receptor related protein 5
dc.subjectprotein fzd8
dc.subjectRhoA guanine nucleotide binding protein
dc.subjectunclassified drug
dc.subjectWnt protein
dc.subjectdishevelled protein
dc.subjectDVL2 protein, human
dc.subjectlow density lipoprotein receptor related protein 5
dc.subjectLRP5 protein, human
dc.subjectRhoA guanine nucleotide binding protein
dc.subjectRHOA protein, human
dc.subjectadult
dc.subjectArticle
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcontrolled study
dc.subjectdiffuse-type gastric carcinoma
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectgastric metastasis
dc.subjectgene amplification
dc.subjectgene expression
dc.subjectgene overexpression
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjecthuman
dc.subjectintestinal type gastric carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectprotein expression
dc.subjectstomach cancer
dc.subjecttumor burden
dc.subjectWnt signaling
dc.subjectcase control study
dc.subjectcomplication
dc.subjectgenetics
dc.subjectHelicobacter pylori
dc.subjectmetabolism
dc.subjectpathology
dc.subjectrisk factor
dc.subjectstomach mucosa
dc.subjectstomach tumor
dc.titleOverexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori
dc.typeArticle

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