Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients

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dc.contributor.authorErgun M.
dc.contributor.authorEyigor S.
dc.contributor.authorKaraca B.
dc.contributor.authorKisim A.
dc.contributor.authorUslu R.
dc.date.accessioned2024-07-22T08:18:09Z
dc.date.available2024-07-22T08:18:09Z
dc.date.issued2013
dc.description.abstractThe aim of this study was to explore the effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in patients who completed breast cancer treatment. Sixty breast cancer patients were randomised into three groups, as supervised exercise group, home exercise group and education group. Angiogenesis and apoptosis-related cytokine levels and quality of life (EORTC QOL-C30: European Organisation for Research and Treatment of Cancer Quality of Life C30), fatigue (Brief Fatigue Inventory) and depression (BDI: Beck Depression Inventory) scores were compared before and after a 12-week exercise programme. After the exercise programme, statistically significant decreases were found in interleukin-8 and neutrophil activating protein-78 levels in the home exercise group (P < 0.05). The education group showed a statistically significant increase in monocyte chemoattractant protein-1 level (P < 0.05). Functional score and global health score of EORTC QOL-C30 in the supervised exercise group and functional score of EORTC QOL-C30 in the home exercise group increased significantly after exercise programme (P < 0.05). BDI score was significantly lower in the supervised exercise group after the exercise programme (P < 0.05). Changes in angiogenesis and apoptosis-related molecules in the study groups suggest a possible effect of exercise on these parameters. Exercise programmes are safe and effective on quality of life and depression in breast cancer patients whose treatments are complete. © 2013 John Wiley & Sons Ltd.
dc.identifier.DOI-ID10.1111/ecc.12068
dc.identifier.issn13652354
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17219
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnalysis of Variance
dc.subjectApoptosis
dc.subjectBreast Neoplasms
dc.subjectCytokines
dc.subjectDepressive Disorder
dc.subjectExercise Therapy
dc.subjectFatigue
dc.subjectFemale
dc.subjectHome Care Services
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectNeovascularization, Pathologic
dc.subjectPatient Education as Topic
dc.subjectProspective Studies
dc.subjectPsychiatric Status Rating Scales
dc.subjectQuality of Life
dc.subjectYoung Adult
dc.subjectangiogenesis
dc.subjectapoptosis
dc.subjectbreast cancer
dc.subjectdepression
dc.subjectexercise
dc.subjectfatigue
dc.subjectquality of life
dc.subjectcytokine
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectanalysis of variance
dc.subjectangiogenesis
dc.subjectapoptosis
dc.subjectarticle
dc.subjectbreast cancer
dc.subjectbreast tumor
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectexercise
dc.subjectfatigue
dc.subjectfemale
dc.subjecthome care
dc.subjecthuman
dc.subjectkinesiotherapy
dc.subjectmetabolism
dc.subjectmethodology
dc.subjectmiddle aged
dc.subjectneovascularization (pathology)
dc.subjectpathology
dc.subjectpatient education
dc.subjectphysiology
dc.subjectprospective study
dc.subjectpsychological aspect
dc.subjectpsychological rating scale
dc.subjectquality of life
dc.subjectrandomized controlled trial
dc.subjectyoung adult
dc.titleEffects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients
dc.typeArticle

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