Postoperative Radiotherapy in the Management of Resected Non-Small-Cell Lung Carcinoma: 10 Years' Experience in a Single Institute

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dc.contributor.authorKarakoyun-Celik O.
dc.contributor.authorYalman D.
dc.contributor.authorBolukbasi Y.
dc.contributor.authorCakan A.
dc.contributor.authorCok G.
dc.contributor.authorOzkok S.
dc.date.accessioned2024-07-22T08:21:01Z
dc.date.available2024-07-22T08:21:01Z
dc.date.issued2010
dc.description.abstractPurpose: This study reports the long term outcomes of postoperative radiotherapy in patients with resection for non-small-cell lung cancer (NSCLC). Methods and Materials: A total of 98 patients with resected NSCLC who received postoperative radiotherapy (PORT) between January 1994 and December 2004 were retrospectively analyzed. The most frequently performed surgical procedure was lobectomy (59 patients), followed by pneumonectomy (25), wedge resection (8), and bilobectomy (6). Postoperative radiotherapy was delivered as an adjuvant treatment in 71 patients, after a wedge resection in 8 patients, and after an R1 resection in 19 patients. The PORT was administered using a Co-60 source in 86 patients and 6-MV photons in 12 patients. A Kaplan-Meier estimate of overall survival, locoregional control, and distant metastasis-free survival were calculated. Results: Stages included I (n =13), II (n = 50), IIIA (n = 29), and IIIB (n = 6). After a median follow-up of 52 months median survival was 61 months. The 5-year overall survival, locoregional control, and distant metastasis-free survival rates for the whole group were 50%, 78%, and 55% respectively. The RT dose, Karnofsky performance status, age, lateralization of the tumor, and pneumonectomy were independent prognostic factors for OAS; anemia and the number of involved lymph nodes were independent prognostic factors for LC. Conclusions: Doses of PORT of greater than 54 Gy were associated with higher death rate in patients with left-sided tumor, which may indicate a risk of radiation-induced cardiac mortality. © 2010 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.ijrobp.2009.02.010
dc.identifier.issn03603016
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18424
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCobalt Radioisotopes
dc.subjectFemale
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPneumonectomy
dc.subjectPostoperative Period
dc.subjectRadiotherapy, Adjuvant
dc.subjectRetrospective Studies
dc.subjectSurvival Analysis
dc.subjectTreatment Outcome
dc.subjectBiological organs
dc.subjectPathology
dc.subjectTumors
dc.subjectcisplatin
dc.subjectAdjuvant radiotherapy
dc.subjectAdjuvant treatment
dc.subjectDeath rates
dc.subjectDistant metastasis
dc.subjectKaplan-Meier estimates
dc.subjectLateralization
dc.subjectLocoregional control
dc.subjectLong-term outcome
dc.subjectLung carcinoma
dc.subjectLymph node
dc.subjectMedian survival
dc.subjectNon small cell lung cancer
dc.subjectOverall survival
dc.subjectPerformance status
dc.subjectPostoperative radiotherapy
dc.subjectPrognostic factors
dc.subjectRadiation-induced
dc.subjectSurgical procedures
dc.subjectSurvival rate
dc.subjectadult
dc.subjectaged
dc.subjectanemia
dc.subjectarticle
dc.subjectbone metastasis
dc.subjectbrain metastasis
dc.subjectcancer adjuvant therapy
dc.subjectcancer chemotherapy
dc.subjectcancer control
dc.subjectcancer mortality
dc.subjectcancer patient
dc.subjectcancer radiotherapy
dc.subjectcancer survival
dc.subjectcobalt therapy
dc.subjectdisease free survival
dc.subjectdisease severity
dc.subjectdistant metastasis
dc.subjectesophagitis
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectleukopenia
dc.subjectliver metastasis
dc.subjectlobectomy
dc.subjectlung adenocarcinoma
dc.subjectlung fibrosis
dc.subjectlung infection
dc.subjectlung metastasis
dc.subjectlung non small cell cancer
dc.subjectlung resection
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple cycle treatment
dc.subjectoverall survival
dc.subjectphoton therapy
dc.subjectpneumonia
dc.subjectpostoperative care
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjecttreatment outcome
dc.subjectRadiotherapy
dc.titlePostoperative Radiotherapy in the Management of Resected Non-Small-Cell Lung Carcinoma: 10 Years' Experience in a Single Institute
dc.typeArticle

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