Prognostic implication of uncontrolled hypertension in hospitalized patients with COVID-19
No Thumbnail Available
Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: In this study, we aimed to investigate the effect of hypertension (HT) and antihypertensive treatment on prognosis, which is one of the cardiovascular risk factors affecting the prognosis of COVID-19. Methods: We included 117 patients diagnosed with COVID-19 by nasopharyngeal polymerase chain reaction (PCR). The patients were divided into a hypertensive group and a control group. Biochemical, complete blood count and imaging data of the patients were recorded. Mortality of patients with and without HT was evaluated. The effect of antihypertensive therapy on mortality was evaluated. Results: In thorax CT, ground glass opacity and pneumonic consolidation were found statistically significantly higher in the hypertensive group (p <0,001). Hospital stay duration (days) of the patients were significantly longer in the hypertensive group and need for intensive care unit was statistically higher in the hypertensive group (p <0,001). Mortality of hypertensive patients was higher than of those without hypertension (p <0,001). There was no statistically significant difference in mortality in antihypertensive treatment groups (p = 0,801). Conclusion: Hypertension is an important risk factor that increases mortality in COVID-19 patients. Uncontrolled hypertension was common in most patients. Inflammatory parameters are higher especially in patients with uncontrolled hypertension. Patients with uncontrolled hypertension have a higher risk of mortality. There is no data to suggesting that the use of ACEI/ARB worsens prognosis. High blood pressure on admission to the hospital is important and the patient’s current antihypertensive therapy should not be discontinued. © 2021, ČKS.
Description
Keywords
angiotensin receptor antagonist , antihypertensive agent , C reactive protein , D dimer , dipeptidyl carboxypeptidase inhibitor , troponin I , adult , anemia , antihypertensive therapy , Article , blood cell count , cardiovascular mortality , cardiovascular risk factor , chronic obstructive lung disease , computer assisted tomography , controlled study , coronary artery disease , coronavirus disease 2019 , coughing , diabetes mellitus , diarrhea , dyspnea , fatigue , female , fever , ground glass opacity , headache , heart failure , heart failure with reduced ejection fraction , hospital patient , hospitalization , human , hyperlipidemia , hypertension , hypertensive patient , intensive care unit , kidney failure , laboratory test , lung consolidation , major clinical study , male , middle aged , nasopharyngeal swab , neutrophil lymphocyte ratio , observational study , peripheral vascular disease , polymerase chain reaction , prognosis , retrospective study , sore throat , thorax pain , thorax radiography , Turkey (republic)