Endothelial dysfunction in preeclampsia: Increased homocysteine and decreased nitric oxide levels

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dc.contributor.authorVar A.
dc.contributor.authorYildirim Y.
dc.contributor.authorOnur E.
dc.contributor.authorKuscu N.K.
dc.contributor.authorUyanik B.S.
dc.contributor.authorGoktalay K.
dc.contributor.authorGuvenc Y.
dc.date.accessioned2024-07-22T08:24:46Z
dc.date.available2024-07-22T08:24:46Z
dc.date.issued2003
dc.description.abstractEndothelial dysfunction underlies the pathogenesis of preeclampsia, but its mechanism has not yet been completely understood. Elevated oxygen free radicals may partially explain the endothelial cell damage. In this study, we have aimed to measure homocysteine (Hcy) and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Nineteen preeclamptic (33.9 ± 1.4 weeks) and 15 gestational-age-matched normal pregnant women (35.5 ± 0.7 weeks) were included in the study. Mean NO level was significantly lower (p < 0.001) and mean Hcy level was significantly higher (p < 0.001) in the preeclamptic group. Elevated Hcy and oxygen free radical levels could decrease NO levels due to the reaction with each other and reduced NO may increase blood pressure and ischemia in preeclamptic patients. We have concluded that increased Hcy and oxygen free radical levels, and decreased NO levels are closely associated with preeclampsia-related endothelial dysfunction. Copyright © 2003 S. Karger AG, Basel.
dc.identifier.DOI-ID10.1159/000074824
dc.identifier.issn03787346
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20124
dc.language.isoEnglish
dc.subjectAdult
dc.subjectBiological Markers
dc.subjectBlood Pressure
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectGestational Age
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectNitric Oxide
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectProteinuria
dc.subjecthomocysteine
dc.subjectnitric oxide
dc.subjectoxygen radical
dc.subjectadult
dc.subjectarticle
dc.subjectblood level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease marker
dc.subjectfemale
dc.subjecthuman
dc.subjectpathophysiology
dc.subjectpreeclampsia
dc.subjectpriority journal
dc.subjectvascular disease
dc.subjectvascular endothelium
dc.titleEndothelial dysfunction in preeclampsia: Increased homocysteine and decreased nitric oxide levels
dc.typeArticle

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