The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients

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dc.contributor.authorKokturk N.
dc.contributor.authorBabayigit C.
dc.contributor.authorKul S.
dc.contributor.authorDuru Cetinkaya P.
dc.contributor.authorAtis Nayci S.
dc.contributor.authorArgun Baris S.
dc.contributor.authorKarcioglu O.
dc.contributor.authorAysert P.
dc.contributor.authorIrmak I.
dc.contributor.authorAkbas Yuksel A.
dc.contributor.authorSekibag Y.
dc.contributor.authorBaydar Toprak O.
dc.contributor.authorAzak E.
dc.contributor.authorMulamahmutoglu S.
dc.contributor.authorCuhadaroglu C.
dc.contributor.authorDemirel A.
dc.contributor.authorKerget B.
dc.contributor.authorBaran Ketencioglu B.
dc.contributor.authorOzger H.S.
dc.contributor.authorOzkan G.
dc.contributor.authorTure Z.
dc.contributor.authorErgan B.
dc.contributor.authorAvkan Oguz V.
dc.contributor.authorKilinc O.
dc.contributor.authorErcelik M.
dc.contributor.authorUlukavak Ciftci T.
dc.contributor.authorAlici O.
dc.contributor.authorNurlu Temel E.
dc.contributor.authorAtaoglu O.
dc.contributor.authorAydin A.
dc.contributor.authorCetiner Bahcetepe D.
dc.contributor.authorGullu Y.T.
dc.contributor.authorFakili F.
dc.contributor.authorDeveci F.
dc.contributor.authorKose N.
dc.contributor.authorTor M.M.
dc.contributor.authorGunluoglu G.
dc.contributor.authorAltin S.
dc.contributor.authorTurgut T.
dc.contributor.authorTuna T.
dc.contributor.authorOzturk O.
dc.contributor.authorDikensoy O.
dc.contributor.authorYildiz Gulhan P.
dc.contributor.authorBasyigit I.
dc.contributor.authorBoyaci H.
dc.contributor.authorOguzulgen I.K.
dc.contributor.authorBorekci S.
dc.contributor.authorGemicioglu B.
dc.contributor.authorBayraktar F.
dc.contributor.authorElbek O.
dc.contributor.authorHanta I.
dc.contributor.authorKuzu Okur H.
dc.contributor.authorSagcan G.
dc.contributor.authorUzun O.
dc.contributor.authorAkgun M.
dc.contributor.authorAltinisik G.
dc.contributor.authorDursun B.
dc.contributor.authorCakir Edis E.
dc.contributor.authorGulhan E.
dc.contributor.authorOner Eyuboglu F.
dc.contributor.authorGultekin O.
dc.contributor.authorHavlucu Y.
dc.contributor.authorOzkan M.
dc.contributor.authorSakar Coskun A.
dc.contributor.authorSayiner A.
dc.contributor.authorKalyoncu A.F.
dc.contributor.authorItil O.
dc.contributor.authorBayram H.
dc.date.accessioned2024-07-22T08:06:00Z
dc.date.available2024-07-22T08:06:00Z
dc.date.issued2021
dc.description.abstractThe COVID-19-related death rate varies between countries and is affected by various risk factors. This multicenter registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2%). Among all cases, 1144 (76.3%) were diagnosed with non-severe pneumonia, whereas 212 (14.1%) had severe pneumonia. Death occurred in 67 patients, corresponding to a mortality rate of 4.5% (95% CI:3.5–5.6). The univariate analysis demonstrated that various factors, including male sex, age ≥65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were positively associated with mortality. Favipiravir, hydroxychloroquine and azithromycin were not associated with survival. Following multivariate analysis, male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were found to be independent risk factors for mortality. Among the biomarkers, procalcitonin levels on the 3rd-5th days of admission showed the strongest associations with mortality (OR: 6.18; 1.6–23.93). This study demonstrated that the mortality rate in hospitalized patients in the early phase of the COVID-19 pandemic was a serious threat and that those patients with male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were at increased risk of mortality; therefore, such patients should be closely monitored. © 2021 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.rmed.2021.106433
dc.identifier.issn09546111
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13341
dc.language.isoEnglish
dc.publisherW.B. Saunders Ltd
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAged
dc.subjectCOVID-19
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPandemics
dc.subjectPopulation Surveillance
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectSurvival Rate
dc.subjectTurkey
dc.subjectalbumin
dc.subjectantibiotic agent
dc.subjectanticoagulant agent
dc.subjectazithromycin
dc.subjectbeta lactam antibiotic
dc.subjectbeta lactamase inhibitor
dc.subjectbicarbonate
dc.subjectC reactive protein
dc.subjectcarbapenem derivative
dc.subjectclarithromycin
dc.subjectcreatine kinase
dc.subjectD dimer
dc.subjectdoxycycline
dc.subjectfavipiravir
dc.subjectferritin
dc.subjecthydroxychloroquine
dc.subjectimmunomodulating agent
dc.subjectlactate dehydrogenase
dc.subjectlopinavir
dc.subjectlow molecular weight heparin
dc.subjectoseltamivir
dc.subjectprocalcitonin
dc.subjectquinolone derivative
dc.subjectsteroid
dc.subjecttocilizumab
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectasthma
dc.subjectatherosclerosis
dc.subjectbronchiectasis
dc.subjectcause of death
dc.subjectcerebrovascular disease
dc.subjectchronic kidney failure
dc.subjectchronic obstructive lung disease
dc.subjectclinical evaluation
dc.subjectclinical outcome
dc.subjectcohort analysis
dc.subjectconfusion
dc.subjectconnective tissue disease
dc.subjectcontrolled study
dc.subjectcoronavirus disease 2019
dc.subjectdiabetes mellitus
dc.subjectdisease association
dc.subjectdyspnea
dc.subjectfemale
dc.subjectheart failure
dc.subjecthospital admission
dc.subjecthospital mortality
dc.subjecthospital patient
dc.subjecthospitalization
dc.subjecthuman
dc.subjectimmune deficiency
dc.subjectinfection risk
dc.subjectinterstitial lung disease
dc.subjectinvasive ventilation
dc.subjectlife threat
dc.subjectliver disease
dc.subjectlung carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality rate
dc.subjectmultiple organ failure
dc.subjectnoninvasive ventilation
dc.subjectoxygen therapy
dc.subjectoxygenation
dc.subjectpandemic
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectsepsis
dc.subjectsurvival rate
dc.subjectTurk (people)
dc.subjectvirus pneumonia
dc.subjectclinical trial
dc.subjectepidemiology
dc.subjecthealth survey
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectmulticenter study
dc.subjectpandemic
dc.subjectturkey (bird)
dc.titleThe predictors of COVID-19 mortality in a nationwide cohort of Turkish patients
dc.typeArticle

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