Can Urinary Gamma Glutamyl Transferase be Used as a Bone Resorption Marker in Postmenopausal Osteoporosis?
| dc.contributor.author | Tikiz, C | |
| dc.contributor.author | Ulman, C | |
| dc.contributor.author | Taneli, F | |
| dc.contributor.author | Acar, EY | |
| dc.contributor.author | Gümüser, G | |
| dc.contributor.author | Horasan, GD | |
| dc.date.accessioned | 2025-04-10T10:29:35Z | |
| dc.date.available | 2025-04-10T10:29:35Z | |
| dc.description.abstract | Objectives: To evaluate whether gamma-glutamyl transferase can be used as a new novel bone resorption marker in postmenopusal osteoporotic subjects. Design and methods: 156 postmenopausal subjects were divided into three groups according to their lumbar spine T-score measured by dual-energy X-ray absorptiometry as normal, (control group, n=56), osteopenic (n=50) and osteoporotic (n=50). Deoxypyridinoline and gamma-glutamyl transferase from urine samples and osteocalcin and bone specific alkaline phosphates from blood samples were assessed. Results: Osteocalcin and bone specific alkaline phosphates levels were increased in osteoporotic group (p<0.05). Although there is a tendency to increase in deoxypyridinoline values in osteoporotic group, this difference did not reach to a statistical significance. No significant differences were observed in urinary gamma-glutamyl transferase levels between the three groups (p>0.05). No significant correlation was found between urinary gamma-glutamyl transferase and deoxypyridinoline, bone specific alkaline phosphates and osteocalcin (p>0.05). Urinary gamma-glutamyl transferase levels showed no significant correlation with neither bone mineral density nor T scores in all subjects (r=0.058 p=0.625, r=-0.074 p=0.533 respectively). Conclusions: Our primary findings did not support the suggestion that urinary g-glutamyl transferase could be used as a potential marker for bone resorption in postmenopusal osteoporotic subjects. | |
| dc.identifier.e-issn | 1303-829X | |
| dc.identifier.issn | 0250-4685 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/36262 | |
| dc.language.iso | English | |
| dc.title | Can Urinary Gamma Glutamyl Transferase be Used as a Bone Resorption Marker in Postmenopausal Osteoporosis? | |
| dc.type | Article |