Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori
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2017
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Abstract
AIM: To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study. METHODS: Data from 3214 adults were obtained with validated questionnaire. Eight hundred and forty-one subjects were randomized to be tested for H. pylori via the urea breath test. "Frequent symptoms" were defined heartburn and/or regurgitation occurring at least weekly. RESULTS: The prevalence of GERD was 22.8%, frequent and occasional heartburn were 9.3%-12.7%, regurgitation were 16.6%-18.7%, respectively. Body mass index (BMI) ≤ 18.5 showed a prevalence of 15%, BMI > 30 was 28.5%. The GERD prevalence was higher in women (26.2%) than men (18.9%) (P < 0001). Overall prevalence of H. pylori was 75.7%. The prevalence was 77.1% in subjects without symptoms vs 71.4% in subjects with GERD (χ2 = 2.6, P = 0.27). Underprivileged with the lowest income people exhibit a higher risk. CONCLUSION: GERD is common in Turkey which reflects both Western and Eastern lifestyles with high rate of H. pylori. The presence of H. pylori had no effect on either the prevalence or the symptom profile of GERD. Subjects showing classical symptoms occasionally exhibit more additional symptoms compared with those without classical symptoms. © 2017 Baishideng Publishing Group Inc. All rights reserved.
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Adult , Breath Tests , Female , Gastroesophageal Reflux , Heartburn , Helicobacter Infections , Helicobacter pylori , Humans , Male , Middle Aged , Prevalence , Random Allocation , Surveys and Questionnaires , Turkey , Urea , alginic acid , antacid agent , histamine H2 receptor antagonist , nonsteroid antiinflammatory agent , proton pump inhibitor , urea , adult , Article , asthma , body mass , coughing , dyspepsia , dysphagia , eructation , female , gastroesophageal reflux , heartburn , Helicobacter pylori , hematemesis , hiccup , hoarseness , human , lowest income group , male , nausea , noncardiac chest pain , odynophagia , pharyngitis , prevalence , sex ratio , Turk (people) , urea breath test , vomiting , breath analysis , gastroesophageal reflux , heartburn , Helicobacter Infections , Helicobacter pylori , isolation and purification , microbiology , middle aged , questionnaire , randomization , Turkey