A retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study

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dc.contributor.authorEsendağli G.
dc.contributor.authorAkarca F.G.
dc.contributor.authorBalci S.
dc.contributor.authorArgon A.
dc.contributor.authorŞengiz Erhan S.
dc.contributor.authorTurhan N.
dc.contributor.authorİnce Zengin N.
dc.contributor.authorHallaç Keser S.
dc.contributor.authorÇelik B.
dc.contributor.authorBulut T.
dc.contributor.authorAbdullazade S.
dc.contributor.authorErden E.
dc.contributor.authorSavaş B.
dc.contributor.authorBostan T.
dc.contributor.authorSağol Ö.
dc.contributor.authorAysal Ağalar A.
dc.contributor.authorKepil N.
dc.contributor.authorKarslioğlu Y.
dc.contributor.authorGünal A.
dc.contributor.authorMarkoç F.
dc.contributor.authorSaka B.
dc.contributor.authorÖzgün G.
dc.contributor.authorÖzdamar Ş.O.
dc.contributor.authorBahadır B.
dc.contributor.authorKaymaz E.
dc.contributor.authorIşık E.
dc.contributor.authorAyhan S.
dc.contributor.authorTunçel D.
dc.contributor.authorÖzgüven Yılmaz B.
dc.contributor.authorÇelik S.
dc.contributor.authorKarabacak T.
dc.contributor.authorErbarut Seven İ.
dc.contributor.authorAtaizi Çelikel Ç.
dc.contributor.authorGücin Z.
dc.contributor.authorEkinci Ö.
dc.contributor.authorAkyol G.
dc.date.accessioned2024-07-22T08:10:21Z
dc.date.available2024-07-22T08:10:21Z
dc.date.issued2018
dc.description.abstractObjective: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. Material and Method: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated. The numbers of adenocarcinomas, dysplasias, intracholecystic neoplasms/adenomas, intestinal metaplasias and reactive atypia were identified with the review of pathology reports and the regional and countrywide incidence rates were presented in percentages. Results: Epithelial changes/lesions were reported in 6% of cholecystectomy materials. Of these epithelial lesions, 7% were reported as adenocarcinoma, 0.9% as high-grade dysplasia, 4% as low-grade dysplasia, 7.8% as reactive/regenerative atypia, 1.7% as neoplastic polyp, and 15.6% as intestinal metaplasia. The remaining lesions (63%) primarily included non-neoplastic polypoids/hyperplastic lesions and antral/pyloric metaplasia. There were also differences between pathology laboratories. Conclusion: The major causes of the difference in reporting these epithelial changes/lesions and neoplasms include the differences related to the institute’s oncological surgery frequency, sampling protocols, geographical dissimilarities, and differences in the diagnoses/interpretations of the pathologists. It seems that the diagnosis may change if new sections are taken from the specimen when any epithelial abnormality is seen during microscopic examination of the cholecystectomy materials. © 2018, Federation of Turkish Pathology Societies. All rights reserved.
dc.identifier.DOI-ID10.5146/tjpath.2017.01404
dc.identifier.issn10185615
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15185
dc.language.isoEnglish
dc.publisherFederation of Turkish Pathology Societies
dc.rightsAll Open Access; Gold Open Access
dc.subjectGallbladder Diseases
dc.subjectGallbladder Neoplasms
dc.subjectHumans
dc.subjectPathology, Surgical
dc.subjectRetrospective Studies
dc.subjectTurkey
dc.subjectadenocarcinoma
dc.subjectArticle
dc.subjectcholecystectomy
dc.subjectdifferential diagnosis
dc.subjectepithelium dysplasia
dc.subjectepithelium tumor
dc.subjectgallbladder cancer
dc.subjectgallbladder carcinoma
dc.subjectgeographic distribution
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectincidence
dc.subjectintestine metaplasia
dc.subjectinvasive carcinoma
dc.subjectmicroscopy
dc.subjectpathologist
dc.subjectpolyp
dc.subjectretrospective study
dc.subjectsampling
dc.subjectTurkey (republic)
dc.subjectclinical trial
dc.subjectgallbladder disease
dc.subjectgallbladder tumor
dc.subjectmulticenter study
dc.subjectpathology
dc.subjectprocedures
dc.subjectstandards
dc.subjectturkey (bird)
dc.titleA retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study
dc.typeArticle

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