Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam
| dc.contributor.author | Keles, GT | |
| dc.contributor.author | Kurutepe, S | |
| dc.contributor.author | Tok, D | |
| dc.contributor.author | Gazi, H | |
| dc.contributor.author | Dinç, G | |
| dc.date.accessioned | 2025-04-10T10:28:40Z | |
| dc.date.available | 2025-04-10T10:28:40Z | |
| dc.description.abstract | Background and objectives: The aim of our study was to investigate the antimicrobial effects of dexmedetomidine and etomidate-lipuro, and to compare these effects with those of midazolam and propofol on Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Acinetobacter baumannii and extended-spectrum beta-lactamase Escherichia coli (E. coli ESBL). Methods: All hypnotic dilutions were exposed to micro-organisms for 0, 30, 60, 120 and 240 min at room temperature in vitro. The inoculums taken from diluted suspensions were re-inoculated on blood agar and incubated for 18-24 h at 35 degrees C after which a count of the colonies was compared. Results: Midazolam reduced the viable cells of S. aureus at 30, 60, 120 and 240 min, and also completely inhibited the growth of E. coli, R aeroginosa, A. baumannii and E. coli ESBL. Dexmedetomidine, etomidate-lipuro and propofol, however, did not inhibit any of the micro-organisms tested. Conclusion: In vitro, midazolam had an antimicrobial effect on E. coli, P aeroginosa, A. baumannii and E. coli ESBL. Like propofol and dexmedetomidine, etomidate-lipuro had no antimicrobial effect on any of the micro-organisms tested. | |
| dc.identifier.e-issn | 1365-2346 | |
| dc.identifier.issn | 0265-0215 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/35485 | |
| dc.language.iso | English | |
| dc.title | Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam | |
| dc.type | Article |