Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma

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dc.contributor.authorKasap E.
dc.contributor.authorBoyacioglu S.Ö.
dc.contributor.authorKorkmaz M.
dc.contributor.authorYuksel E.S.
dc.contributor.authorÜnsal B.
dc.contributor.authorKahraman E.
dc.contributor.authorÖzütemiz Ö.
dc.contributor.authorYuceyar H.
dc.date.accessioned2024-07-22T08:19:20Z
dc.date.available2024-07-22T08:19:20Z
dc.date.issued2012
dc.description.abstractGastroesophageal reflux disease is a risk factor for esophageal adenocarcinoma yet studies that have investigated the relationship between erosive esophagitis and esophageal adenocarcinoma have usually focused on symptom-related evidence or polymorphisms. There are no epigenetic gene expression studies on this topic. In this study, we aimed to evaluate the relationship between erosive esophagitis and esophageal adenocarcinoma to identify whether there is a genetic predisposition for esophageal adenocarcinoma. The Human Epigenetic Chromatin Modification Enzyme RT 2 Profiler™ PCR array (PAHS-085A) was used to detect the expression of 84 key genes encoding enzymes. This was carried out prospectively for samples from 60 patients (20 patients as a control group, 20 patients with erosive esophagitis and 20 patients with esophageal adenocarcinoma). AURKA, AURKB, NEK6 were expressed at significantly higher levels in esophageal adenocarcinoma compared to the control group. MBD2 was expressed at significantly lower levels in the esophageal adenocarcinoma group compared to the control group. AURKA, AURKC, HDAC9 and NEK6 were expressed at significantly higher levels in erosive esophagitis compared to the control group. There was no difference in upregulated gene expression between the erosive esophagitis and esophageal adenocarcinoma. MBD2 was significantly downregulated in esophageal adenocarcinoma compared to erosive esophagitis. NEK6 and AURKA were significantly upregulated in esophageal adenocarcinoma and erosive esophagitis compared to the control group. This is a novel study on the genetic predisposition for erosive esophagitis and esophageal adenocarcinoma. AURKA and NEK6 are two promising genetic markers for erosive esophagitis and esophageal adenocarcinoma.
dc.identifier.DOI-ID10.3892/etm.2012.561
dc.identifier.issn17921015
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17640
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectaurora A kinase
dc.subjectarticle
dc.subjectaurora A kinase gene
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdown regulation
dc.subjectesophageal adenocarcinoma
dc.subjectgene
dc.subjectgene expression regulation
dc.subjectgenetic marker
dc.subjectgenetic predisposition
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectnever in mitosis gene A related kinase 6 gene
dc.subjectpolymerase chain reaction
dc.subjectreflux esophagitis
dc.subjectupregulation
dc.titleAurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma
dc.typeArticle

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