Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: An empirical cross-sectional study

Simple item page
dc.contributor.authorAydemir Ö.
dc.contributor.authorÇubukçuoğlu Z.
dc.contributor.authorErdin S.
dc.contributor.authorTaş C.
dc.contributor.authorOnur E.
dc.contributor.authorBerk M.
dc.date.accessioned2024-07-22T08:15:20Z
dc.date.available2024-07-22T08:15:20Z
dc.date.issued2014
dc.description.abstractObjective: This study aimed to evaluate the relationship between oxidative stress markers and cognitive functions and domains of psychosocial functioning in bipolar disorder.; Methods: Oxidative stress markers, cognitive functions, and domains of psychosocial functioning were evaluated in 51 patients with bipolar disorder who were in remission. Correlation analyses between these parameters were calculated with data controlled for duration of illness and number of episodes.; Results: There was no statistically significant correlation between oxidative stress markers and cognitive functions. In terms of psychosocial functioning, significant correlations were found between malondialdehyde and sense of stigmatization (r = -0.502); household activities and superoxide dismutase (r = 0.501); participation in social activities and nitric oxide (r = 0.414); hobbies and leisure time activities and total glutathione (r = -0.567), superoxide dismutase (r = 0.667), and neurotrophin 4 (r = 0.450); and taking initiative and self-sufficiency and superoxide dismutase (r = 0.597). There was no correlation between other domains of psychosocial functioning and oxidative stress markers.; Conclusion: These results imply that oxidative stress markers do not appear to correlate clearly with cognitive impairment and reduced psychosocial functioning. However, there were some associations between selected oxidative markers and activity-oriented functional markers. This may represent a true negative association, or may be an artifact of oxidative stress being a state rather than a trait marker. © 2014 Associação Brasileira de Psiquiatria.
dc.identifier.DOI-ID10.1590/1516-4446-2013-1299
dc.identifier.issn15164446
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16718
dc.language.isoEnglish
dc.publisherAssociacao Brasileira de Psiquiatria
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectActivities of Daily Living
dc.subjectAdult
dc.subjectBiological Markers
dc.subjectBipolar Disorder
dc.subjectCase-Control Studies
dc.subjectCognition
dc.subjectCognition Disorders
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectOxidative Stress
dc.subjectPsychiatric Status Rating Scales
dc.subjectSocial Adjustment
dc.subjectTime Factors
dc.subjectcyanocobalamin
dc.subjectfolic acid
dc.subjectglutathione
dc.subjecthomocysteine
dc.subjectmalonaldehyde
dc.subjectneurotrophin 4
dc.subjectnitric oxide
dc.subjectpsychotropic agent
dc.subjectsuperoxide dismutase
dc.subjectbiological marker
dc.subjectadult
dc.subjectArticle
dc.subjectbipolar disorder
dc.subjectBipolar Disorder Functioning Questionnaire
dc.subjectcognition
dc.subjectcognitive defect
dc.subjectcontinuous performance test
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectcross-sectional study
dc.subjectdisease duration
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectHamilton scale
dc.subjecthigh performance liquid chromatography
dc.subjecthousehold
dc.subjecthuman
dc.subjectleisure
dc.subjectLikert scale
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmonotherapy
dc.subjectneuropsychological test
dc.subjectoxidative stress
dc.subjectpsychologic test
dc.subjectquestionnaire
dc.subjectremission
dc.subjectrest
dc.subjectRey Auditory Verbal Learning Test
dc.subjectsense of stigmatization
dc.subjectSerial Digit Learning Test
dc.subjectsocial behavior
dc.subjectsocial psychology
dc.subjectStroop test
dc.subjectStructured Clinical Interview for DSM Disorders
dc.subjectWisconsin Card Sorting Test
dc.subjectYoung Mania Rating Scale
dc.subjectbipolar disorder
dc.subjectcase control study
dc.subjectcognition
dc.subjectdaily life activity
dc.subjectmiddle aged
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpsychological rating scale
dc.subjectpsychology
dc.subjectsocial adaptation
dc.subjecttime
dc.titleOxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: An empirical cross-sectional study
dc.typeArticle

Files

Collections

Scopus Koleksiyonu