Melatonin improves methanol intoxication-induced oxidative liver injury in rats

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dc.contributor.authorKurcer Z.
dc.contributor.authorOǧuz E.
dc.contributor.authorIraz M.
dc.contributor.authorFadillioglu E.
dc.contributor.authorBaba F.
dc.contributor.authorKoksal M.
dc.contributor.authorOlmez E.
dc.date.accessioned2024-07-22T08:23:01Z
dc.date.available2024-07-22T08:23:01Z
dc.date.issued2007
dc.description.abstractThis study was performed to evaluate the effect of melatonin on methanol-induced liver injury. We evaluated the levels of malondialdehyde (MDA), protein carbonylation (PC), myeloperoxidase (MPO) activities and to assess lipid peroxidation, protein oxidation, neutrophil accumulation and nitrite which is a stable end product of nitric oxide respectively. We also studied superoxide dismutase, catalase, and glutathione peroxidase activities of liver tissue to evaluate the changes in the antioxidant status. Histopathological alterations were also determined. The experiment was performed on Wistar rats, which received intragastric 3 g/kg methanol as a 50% solution in isotonic saline once. After 6 and 24 hr all the drug received and intoxicated rats were killed under anesthesia. Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities. Additionally in melatonin treated group piecemeal necrosis, lobular lytic necrosis, and portal inflammation returned to normal histologic appearances when compared with methanol administration. In conclusion, melatonin has protective effects against methanol-induced hepatic injury. © 2007 The Authors.
dc.identifier.DOI-ID10.1111/j.1600-079X.2007.00441.x
dc.identifier.issn07423098
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19345
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.rightsAll Open Access; Bronze Open Access
dc.subjectcatalase
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmelatonin
dc.subjectmethanol
dc.subjectmyeloperoxidase
dc.subjectnitric oxide
dc.subjectnitrite
dc.subjectsuperoxide dismutase
dc.subjectanimal euthanasia
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectarticle
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectexperimental study
dc.subjecthepatitis
dc.subjecthistopathology
dc.subjectlipid peroxidation
dc.subjectliver hilus
dc.subjectliver injury
dc.subjectliver necrosis
dc.subjectliver protection
dc.subjectmale
dc.subjectmethanol poisoning
dc.subjectneutrophil chemotaxis
dc.subjectnonhuman
dc.subjectoxidation
dc.subjectoxidative stress
dc.subjectprotein carbonylation
dc.subjectrat
dc.subjectWistar rat
dc.titleMelatonin improves methanol intoxication-induced oxidative liver injury in rats
dc.typeArticle

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