Angiotensin-converting enzyme genotype and acute pancreatitis in Turkey

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dc.contributor.authorKasap E.
dc.contributor.authorAkyildiz M.
dc.contributor.authorTekin F.
dc.contributor.authorAkarca U.
dc.date.accessioned2024-07-22T08:21:51Z
dc.date.available2024-07-22T08:21:51Z
dc.date.issued2009
dc.description.abstractThe renin-angiotensin system (RAS) has been implicated in the pathogenesis of acute and chronic pancreatitis. Angiotensin-converting enzyme (ACE) is the key enzyme which activates RAS. The ACE intron 16 insertion/ deletion (I/D) polymorphism is associated with ACE activity and is considered to be a risk factor for several inflammatory processes. We investigated this polymorphism in 68 patients with acute pancreatitis (AP) and 157 healthy Turkish control subjects. Patients were evaluated with ultrasonography, abdominal tomography and laboratory markers and grouped by status for diabetes mellitus (DM), hypertension (HT), and both these diseases and by etiology. Genotyping of the I/D polymorphism was performed by polymerase chain reaction (PCR). The DD genotype was more prevalent in healthy controls, however, genotype II was significantly more frequent in AP patients (p <0.05). In severe AP patients, the genotype II frequency was significantly higher than in controls (p <0.05). Acute pancreatitis patients with both DM and HT had lower frequencies of genotype DD and of the D allele, and higher frequencies of genotype II and of the I allele than patients with either DM or HT (p <0.05).
dc.identifier.DOI-ID10.2478/v10034-010-0005-9
dc.identifier.issn13110160
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18793
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectdipeptidyl carboxypeptidase
dc.subjectacute pancreatitis
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectchronic pancreatitis
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectdisease severity
dc.subjectDNA polymorphism
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectgene deletion
dc.subjectgene frequency
dc.subjectgene insertion
dc.subjectgenotype
dc.subjecthuman
dc.subjecthypertension
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectrenin angiotensin aldosterone system
dc.subjectTurkey (republic)
dc.titleAngiotensin-converting enzyme genotype and acute pancreatitis in Turkey
dc.typeArticle

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