Activation of peripheral opioid receptors has no effect on heart rate variability

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dc.contributor.authorEllidokuz E.
dc.contributor.authorKaya D.
dc.contributor.authorUslan I.
dc.contributor.authorÇelik A.
dc.contributor.authorEsen A.M.
dc.contributor.authorBarutça I.
dc.date.accessioned2024-07-22T08:22:18Z
dc.date.available2024-07-22T08:22:18Z
dc.date.issued2008
dc.description.abstractOpioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11 healthy subjects. Trimebutine (200 mg) or placebo was administered orally at random in a double-blind, cross-over manner. Continuous electrocardiography recordings were obtained before and after drug administration during three states: rest, controlled breathing, and a hand grip exercise. Heart rate variability analysis showed that there was no significant difference between subjects administered with placebo or trimebutine throughout rest, controlled breathing, or the hand grip exercise. We concluded that trimebutine, in clinical doses, has no significant effect on cardiac autonomic functions. © 2008 Springer.
dc.identifier.DOI-ID10.1007/s10286-008-0469-9
dc.identifier.issn09599851
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19022
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAutonomic Nervous System
dc.subjectBlood Pressure
dc.subjectCross-Over Studies
dc.subjectDose-Response Relationship, Drug
dc.subjectDouble-Blind Method
dc.subjectElectrocardiography
dc.subjectGastrointestinal Agents
dc.subjectGastrointestinal Motility
dc.subjectHand Strength
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectMale
dc.subjectReceptors, Opioid
dc.subjectRespiratory Mechanics
dc.subjectTrimebutine
dc.subjectopiate receptor
dc.subjectplacebo
dc.subjecttrimebutine
dc.subjectadult
dc.subjectarticle
dc.subjectautonomic innervation
dc.subjectbreathing
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcrossover procedure
dc.subjectdose response
dc.subjectdouble blind procedure
dc.subjectdrug effect
dc.subjectelectrocardiography
dc.subjecthand grip
dc.subjectheart function
dc.subjectheart rate variability
dc.subjecthuman
dc.subjectmale
dc.subjectnormal human
dc.subjectrandomization
dc.subjectrandomized controlled trial
dc.subjectreceptor intrinsic activity
dc.subjectrest
dc.titleActivation of peripheral opioid receptors has no effect on heart rate variability
dc.typeArticle

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