Effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma

Simple item page
dc.contributor.authorErkin E.F.
dc.contributor.authorTarhan S.
dc.contributor.authorKayikçioǧlu Ö.R.
dc.contributor.authorDeveci H.
dc.contributor.authorGüler C.
dc.contributor.authorGöktan C.
dc.date.accessioned2024-07-22T08:24:38Z
dc.date.available2024-07-22T08:24:38Z
dc.date.issued2004
dc.description.abstractPURPOSE. To evaluate the effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma (POAG) by means of an observer-masked, prospective clinical study. METHODS. Thirty-two patients with newly diagnosed POAG were included in the study. The patients were randomized into two groups. The first group was treated with betaxolol 0.50% twice daily and the second group with latanoprost 0.005% once daily. Baseline and post-treatment examinations on the first and third months of treatment included intraocular pressure (IOP) measurement, automated visual field testing, and ocular blood flow assessment. For evaluation of visual fields, mean defect and pattern standard deviation indices were used. Ocular blood flow was assessed by means of color Doppler imaging of the central retinal artery (CRA) and the temporal short posterior ciliary artery (PCA). For each vessel, peak systolic (PSV) and end-diastolic (EDV) blood flow velocities were measured and resistivity index (RI) calculated. RESULTS. After exclusion of one noncompliant patient, the study was completed with 31 eyes of 31 patients. Both drugs significantly reduced IOP (p<0.05). The mean IOP lowering effect of latanoprost was significantly higher than that of betaxolol (p=0.03). Visual field indices exhibited no significant changes in either group (p>0.05). There were no significant changes in PSV or EDV measurements of CRA or PCA in either group (p>0.05). RI decreased in both CRA and PCA with both drugs. The mean changes between baseline and 3 month blood flow measurements were not significantly different between betaxolol and latanoprost (p>0.05). CONCLUSIONS. Over a treatment period of 3 months, both betaxolol and latanoprost tended to improve ocular blood flow without one of them being superior to the other. The results suggest that the direct (non IOP-dependent) influence on ocular circulation is better for betaxolol than for latanoprost. In addition, neither drug caused significant generalized improvements in visual fields during this period.
dc.identifier.DOI-ID10.1177/112067210401400305
dc.identifier.issn11206721
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20064
dc.language.isoEnglish
dc.publisherWichtig Editore s.r.l.
dc.subjectAntihypertensive Agents
dc.subjectBetaxolol
dc.subjectBlood Flow Velocity
dc.subjectCiliary Arteries
dc.subjectFemale
dc.subjectGlaucoma, Open-Angle
dc.subjectHumans
dc.subjectIntraocular Pressure
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOphthalmic Solutions
dc.subjectProspective Studies
dc.subjectProstaglandins F, Synthetic
dc.subjectRegional Blood Flow
dc.subjectRetinal Artery
dc.subjectTonometry, Ocular
dc.subjectUltrasonography, Doppler, Color
dc.subjectVisual Fields
dc.subjectbetaxolol
dc.subjectlatanoprost
dc.subjectantihypertensive agent
dc.subjectbetaxolol
dc.subjecteye drops
dc.subjectlatanoprost
dc.subjectprostaglandin F
dc.subjectarticle
dc.subjectblood flow velocity
dc.subjectciliary artery
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcolor ultrasound flowmetry
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjecteye blood flow
dc.subjectfemale
dc.subjecthuman
dc.subjectintraocular pressure
dc.subjectmale
dc.subjectopen angle glaucoma
dc.subjectperimetry
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectretina artery
dc.subjectstatistical analysis
dc.subjectvisual field
dc.subjectblood flow
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectmiddle aged
dc.subjectoculoplethysmography
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectprospective study
dc.titleEffects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma
dc.typeArticle

Files

Collections

Scopus Koleksiyonu