Osteoporosis in women with breast cancer and its effect on quality of life: A pilot study

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dc.contributor.authorTuran Y.
dc.contributor.authorKocaaga Z.
dc.contributor.authorKarakoyun-Celik O.
dc.contributor.authorGurgan A.
dc.contributor.authorDuransoy A.
dc.date.accessioned2024-07-22T08:21:45Z
dc.date.available2024-07-22T08:21:45Z
dc.date.issued2009
dc.description.abstractPurpose: The primary aim of this study was to evaluate the risk of osteoporosis (OP) in patients who had received adjuvant chemotherapy for breast cancer. The secondary aim was to investigate the effect of OP on the quality of life of these patients. Patients and methods: Twenty-six patients with breast cancer and 21 healthy controls were recruited into the study. All breast cancer patients were treated with 6 cycles of adjuvant chemotherapy. Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometry (DXA). Short Form-36 (SF-36) questionnaire was used to assess the quality of life. Results: The mean lumbar area BMD value was significantly lower in patients with breast cancer than in healthy controls (p=0.017). There were no significant differences in the femoral area BMD measurements between the groups. OP was more pronounced after 24 months of the last chemotherapy course than in the first 12 months (p=0.04). The most affected domain of the SF-36 in patients with breast cancer was the physical role. Conclusion: Adjuvant chemotherapy increases the risk of accelerated bone loss in the lumbar spine. OP should be investigated during follow-up in order to improve the quality of life of the surviving breast cancer patients. © 2009 Zerbinis Medical Publications.
dc.identifier.issn11070625
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18766
dc.language.isoEnglish
dc.subjectAbsorptiometry, Photon
dc.subjectAdult
dc.subjectAged
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectBone Density
dc.subjectBreast Neoplasms
dc.subjectChemotherapy, Adjuvant
dc.subjectCyclophosphamide
dc.subjectEpirubicin
dc.subjectFemale
dc.subjectFluorouracil
dc.subjectHumans
dc.subjectLumbar Vertebrae
dc.subjectMenopause
dc.subjectMiddle Aged
dc.subjectOsteoporosis
dc.subjectPilot Projects
dc.subjectQuality of Life
dc.subjectantineoplastic agent
dc.subjectarticle
dc.subjectbone density
dc.subjectbreast cancer
dc.subjectcancer adjuvant therapy
dc.subjectcancer survival
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdual energy X ray absorptiometry
dc.subjecthuman
dc.subjectlumbar spine
dc.subjectmultiple cycle treatment
dc.subjectosteoporosis
dc.subjectpilot study
dc.subjectquality of life
dc.subjectquestionnaire
dc.subjectShort Form 36
dc.subjecttreatment duration
dc.titleOsteoporosis in women with breast cancer and its effect on quality of life: A pilot study
dc.typeArticle

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