Synthesis and in vitro characterization of superparamagnetic γ-Fe2O3-containing 13–93 bioactive glasses for bone cancer therapy

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dc.contributor.authorSaatci M.
dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorAtmaca H.
dc.date.accessioned2024-07-22T08:03:42Z
dc.date.available2024-07-22T08:03:42Z
dc.date.issued2022
dc.description.abstractOsteosarcoma is one of the most common types of bone cancer, which generally starts in the long bones. In this study, superparamagnetic maghemite-containing (2, 5, 10, 20 wt%) bioactive glass powders were prepared for the treatment of osteosarcoma. For this purpose, maghemite nanoparticles were synthesized using the co-precipitation technique, and maghemite-containing bioactive glass-ceramic composites were fabricated through the sol-gel process. The structural, morphological, thermal, and magnetic properties and the in vitro bioactivity of the prepared bioactive glasses were investigated. In vitro cytotoxicity was examined using SaOS-2 and MC3T3-E1 cells. The fluorouracil (5-FU) release behavior of the studied bioactive glass powders was also monitored in phosphate-buffered saline as a function of time. Results revealed that synthesized maghemite nanoparticles as well as the maghemite-containing bioactive glass-ceramic composites have superparamagnetic properties. They have high bioactivity, with up to 5 wt% maghemite content. Prepared bioactive glass composites have no cytotoxicity against osteosarcoma and pre-osteoblast cells at low concentrations. Drug-loaded bioactive glass powder showed sustained release behavior. Overall results indicated that prepared glass composites have a high potential to be used in magnetic hyperthermia and anticancer drug release applications for the treatment of bone cancer. © 2022 Elsevier Ltd and Techna Group S.r.l.
dc.identifier.DOI-ID10.1016/j.ceramint.2022.08.017
dc.identifier.issn02728842
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12395
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectBioactivity
dc.subjectControlled drug delivery
dc.subjectDiseases
dc.subjectGlass ceramics
dc.subjectHematite
dc.subjectHyperthermia therapy
dc.subjectNanoparticles
dc.subjectPowders
dc.subjectPrecipitation (chemical)
dc.subjectSol-gel process
dc.subjectSol-gels
dc.subjectSuperparamagnetism
dc.subjectSynthesis (chemical)
dc.subjectTargeted drug delivery
dc.subjectBioactive glass ceramics
dc.subjectBone cancer
dc.subjectGlass ceramic composites
dc.subjectGlass Powder
dc.subjectIn-vitro
dc.subjectMaghemite nanoparticle
dc.subjectMaghemites
dc.subjectOsteosarcomas
dc.subjectSuperparamagnetics
dc.subjectSynthesised
dc.subjectBioactive glass
dc.titleSynthesis and in vitro characterization of superparamagnetic γ-Fe2O3-containing 13–93 bioactive glasses for bone cancer therapy
dc.typeArticle

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