The addition of metoclopramide to the PCA with tramadol; [Tramadol ile yapilan PCA'ya metoklopramid eklenmesi]

Luleci N.; Erincler T.; Tekin I.; Gumus B.; Erbuyun K.; Tutan A.

The addition of metoclopramide to the PCA with tramadol; [Tramadol ile yapilan PCA'ya metoklopramid eklenmesi]

Date

1998

Authors

Abstract

Nausea and vomiting is a major problem during opioid administrations. In PCA (Patient Controlled Analgesia), sufficient analgesia can be obtained with smaller doses of opioids but nause and vomiting may still a great problem. Addition of antiemetics to opioids in PCA applications is not studied adequately. In this study we added metoclopramide to tramadol hydrochloride (TH) TH for PCA and evaluated its effects on the nausea and vomiting. 36 patients in ASA I-III, were allocated randomly into two groups (each had 18 patients) to receive patient-controlled analgesia with either TH and metoclopramide combination or with TH alone. Bolus doses of TH 20 mg (limited to 200 mg in four hours) alone used in the first and combined with metoclopramide 5 mg in the second group were used with a lockout time of 15 min. During the first 24 h. after surgery the VAS scores and side effects were recorded. The patients in metoclopramide group have significantly lower PAC scores (p<0.05). As a result nausea and vomiting can be reduced by addition of metoclopramide to TH in PCA. The same method maybe used also with of other opioids.