The effects of propofol and thiopentone on natural cytotoxic cell activity; [Tiyopenton ve propofol'un naturel killer hucre aktivitesine etkileri]

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dc.contributor.authorLuleci N.
dc.contributor.authorErincler T.
dc.contributor.authorTekin I.
dc.contributor.authorSengil A.Z.
dc.contributor.authorTutan A.
dc.date.accessioned2024-07-22T08:25:49Z
dc.date.available2024-07-22T08:25:49Z
dc.date.issued1998
dc.description.abstractThe effects of thiopentone and propofol on Natural Killer cell activity were studied by the use of candidial colony inhibition method in venous blood samples from healthy volunteers. Following three hours of incubation mean CFU (colony forming unit) was 72.1 in control group while it was 66.3 and 64.1 CFU in samples containing 15 and 150 μL/mL of thiopentone respectively; and 67 and 63.8 in samples containing 5 and 50 μL/mL of propofol respectively. With small doses of propofol and thiopentone colony inhibition was 7% and 8% respectively while high doses leaded higher inhibitions of 11.5% and 11% respectively. It was concluded that a significant increase in anticandidal activity of natural cytotoxic cells is observed with high concentrations of thiopentone and propofol (p<0.01). However, the increase of this activity is not significant in anaesthetic concentrations used in clinical practice.
dc.identifier.issn10165150
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20614
dc.language.isoTurkish
dc.subjectpropofol
dc.subjectthiopental
dc.subjectantifungal activity
dc.subjectarticle
dc.subjectcandida
dc.subjectcolony forming unit
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectnatural killer cell
dc.subjectnonhuman
dc.titleThe effects of propofol and thiopentone on natural cytotoxic cell activity; [Tiyopenton ve propofol'un naturel killer hucre aktivitesine etkileri]
dc.typeArticle

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