The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: A preliminary study

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dc.contributor.authorAydemir O.
dc.contributor.authorDeveci A.
dc.contributor.authorTaneli F.
dc.date.accessioned2024-07-22T08:24:06Z
dc.date.available2024-07-22T08:24:06Z
dc.date.issued2005
dc.description.abstractRecent studies suggested a role of brain-derived neurotrophic factor (BDNF) in depression. While BDNF levels are lower in depressed patients, antidepressant treatment increases serum BDNF levels of depressed patients. Our study aims to test the effect of chronic venlafaxine treatment on serum BDNF levels in patients with a major depressive disorder. Ten patients diagnosed as major depressive disorder according to DSM-IV are included in the study. Two of the patients had their first episode and were drug-naive, the other eight patients were drug-free for at least 4 weeks. The severity of depression was assessed with Hamilton Depression Rating Scale (HDRS). The control group consisted of ten age- and sex-matched subjects without any psychiatric disorder. Blood samples were collected at the baseline and after 12 weeks of antidepressant treatment (during remission). At the baseline the mean serum BDNF level was 17.9±9.1 ng/ml and the mean HDRS score was 23.2±4.6. Serum BDNF levels of the study group were significantly lower than in the control group (31.6±8.6 ng/ml). At the end of the study, the mean serum BDNF level was 34.6±7.1 ng/ml whereas the mean HDRS score was 8.2±3.9. From the baseline to the remission after 12 weeks of treatment, the increase in serum BDNF level and the decrease in HDRS score were statistically significant, respectively. When we compared the serum BDNF level of depressed patients at remission to that of the controls, there was no statistically significant difference. This study shows that venlafaxine treatment of depression improves serum BDNF level which may be considered as a nonspecific peripheral marker of depression. © 2004 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.pnpbp.2004.11.009
dc.identifier.issn02785846
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19830
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.subjectantidepressant agent
dc.subjectbrain derived neurotrophic factor
dc.subjectvenlafaxine
dc.subjectadult
dc.subjectage distribution
dc.subjectarticle
dc.subjectblood sampling
dc.subjectclinical article
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectdiagnostic and statistical manual of mental disorders
dc.subjectdiagnostic procedure
dc.subjectdisease severity
dc.subjectdrug effect
dc.subjectfemale
dc.subjectHamilton scale
dc.subjecthealth status
dc.subjecthuman
dc.subjectmajor depression
dc.subjectmale
dc.subjectmental disease
dc.subjectmental patient
dc.subjectpsychiatric diagnosis
dc.subjectpsychiatric treatment
dc.subjectrating scale
dc.subjectscoring system
dc.subjectserum
dc.subjectsex difference
dc.subjectstatistical significance
dc.subjecttreatment outcome
dc.titleThe effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: A preliminary study
dc.typeArticle

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