Pre-ischemic administration of nitric oxide synthase inhibitors reduced germ cell apoptosis after spermatic vessel ligation in the rat testis

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dc.contributor.authorTaneli F.
dc.contributor.authorVatansever S.
dc.contributor.authorUlman C.
dc.contributor.authorGiray G.
dc.contributor.authorGenc A.
dc.contributor.authorTaneli C.
dc.date.accessioned2024-07-22T08:23:50Z
dc.date.available2024-07-22T08:23:50Z
dc.date.issued2005
dc.description.abstractIntroduction: The Fowler-Stephens maneuver, a mode of spermatic vessel ligation, is a method of choice in the management of high testes. The aim of the present study is to investigate the effects of pre-ischemic administration of NG-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase (NOS) inhibitor, in preventing testicular ischemic damage and germ cell-specific apoptosis in rats. Materials and Methods: 30 min before ligation of the spermatic vessels, L-NAME was administered intraperitoneally to a group of rats and saline was given to another group of rats (controls). Biochemical assessments of NO and germ cell-specific apoptosis were performed. Results: Testicular NO levels in the L-NAME group showed significant decreases in the ipsilateral (p = 0.004) and contralateral (p = 0.015) testes in relation to those of the control group. The apoptotic indices were found in 2.3% of the L-NAME group and 3.1% of the control group. Conclusion: Pre-ischemic administrations of the NOS inhibitor, L-NAME, effectively decreased NO production and to some degree caused a reduction in germ cell apoptosis in the rat testes after spermatic vessel ligation. Further studies are mandatory to confirm our preliminary results and to address the potential introduction of NOS inhibitors into clinical practice. Copyright © 2005 S. Karger AG.
dc.identifier.DOI-ID10.1159/000085932
dc.identifier.issn00421138
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19716
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCryptorchidism
dc.subjectDisease Models, Animal
dc.subjectEnzyme Inhibitors
dc.subjectIn Situ Nick-End Labeling
dc.subjectIschemia
dc.subjectLigation
dc.subjectMale
dc.subjectNG-Nitroarginine Methyl Ester
dc.subjectNitric Oxide Synthase
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSpermatic Cord
dc.subjectSpermatozoa
dc.subjectTestis
dc.subjectn(g) nitroarginine methyl ester
dc.subjectnitric oxide synthase inhibitor
dc.subjectsodium chloride
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectchemical analysis
dc.subjectclinical practice
dc.subjectcontrolled study
dc.subjectgerm cell
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstatistical significance
dc.subjecttestis
dc.titlePre-ischemic administration of nitric oxide synthase inhibitors reduced germ cell apoptosis after spermatic vessel ligation in the rat testis
dc.typeArticle

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