The effect of tirofiban on ST segment resolution in patients with non-ST elevated myocardial infarction

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dc.contributor.authorBayturan Ö.
dc.contributor.authorBilge A.R.
dc.contributor.authorSeküri C.
dc.contributor.authorÜtük O.
dc.contributor.authorTikiz H.
dc.contributor.authorEser E.
dc.contributor.authorTezcan U.K.
dc.date.accessioned2024-07-22T08:24:16Z
dc.date.available2024-07-22T08:24:16Z
dc.date.issued2004
dc.description.abstractST segment resolution in ST elevated myocardial infarction has independent predictive value for congestive heart failure and death at 30 days. ST segment depression in unstable angina pectoris (UAP) and non-ST elevated myocardial infarction (NSTEMI) predicts high risk of MI and death and may discriminate patients likely to have greater benefit from aggressive antithrombotic and interventional therapy. This study assessed the effect of tirofiban added to conventional treatment on ST segment resolution in NSTEMI patients. Sixty-four patients were randomized to one of the two groups: 32 patients received conventional treatment while tirofiban was added in the second group of 32 patients. In the first group, 6 patients refused to participate further after giving initial informed consent while 1 patient in the tirofiban group dropped out. We had 26 patients (mean age, 59 years) in the conventional treatment group and 31 patients (mean age, 59 years) received also tirofiban. Tirofiban was administered by intravenous infusion over a 72 hour period. More than 50% regression of depression was considered to be ST segment resolution. The characteristics of the two groups were comparable (Table I). The ST segment resolution evolution did not differ at the 4th and 24th hours between the two groups. Significant differences occurred in the 72nd hour ECG (Table III). ST resolution was present in 67.9% of the tirofiban patients and in 32.1% of the conventional treatment group (P < 0.05). Tirofiban treatment was not associated with an increase in major bleeding even though there was a trend toward an increase in minor bleeding cases and did not influence the occurrence of refractory angina pectoris.
dc.identifier.DOI-ID10.1536/jhj.45.913
dc.identifier.issn00214868
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19899
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access; Green Open Access
dc.subjectElectrocardiography
dc.subjectFemale
dc.subjectFibrinolytic Agents
dc.subjectHumans
dc.subjectInfusions, Intravenous
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectPlatelet Glycoprotein GPIIb-IIIa Complex
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectTreatment Outcome
dc.subjectTyrosine
dc.subjectacetylsalicylic acid
dc.subjectanticoagulant agent
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectheparin
dc.subjectnitrate
dc.subjecttirofiban
dc.subjecttroponin T
dc.subjectdrug derivative
dc.subjectfibrinogen receptor
dc.subjectfibrinolytic agent
dc.subjecttirofiban
dc.subjecttyrosine
dc.subjectadult
dc.subjectaged
dc.subjectangiocardiography
dc.subjectarticle
dc.subjectbleeding
dc.subjectchi square test
dc.subjectclinical trial
dc.subjectcongestive heart failure
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcoronary artery recanalization
dc.subjectelectrocardiogram
dc.subjectfemale
dc.subjectfollow up
dc.subjectheart infarction
dc.subjecthigh risk patient
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectprediction
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectrank sum test
dc.subjectST segment depression
dc.subjectST segment elevation
dc.subjectstatistical significance
dc.subjecttreatment outcome
dc.subjecttreatment refusal
dc.subjectTurkey (republic)
dc.subjectunstable angina pectoris
dc.subjectdrug antagonism
dc.subjectelectrocardiography
dc.subjectheart infarction
dc.subjectintravenous drug administration
dc.subjectmiddle aged
dc.subjectpathophysiology
dc.subjectprediction and forecasting
dc.subjectprognosis
dc.titleThe effect of tirofiban on ST segment resolution in patients with non-ST elevated myocardial infarction
dc.typeArticle

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